AIMC Topic: Gene Expression Regulation

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Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci.

Arteriosclerosis, thrombosis, and vascular biology Mar 10, 2016
OBJECTIVE: Recent genome-wide association studies of coronary artery disease (CAD) have revealed 58 genome-wide significant and 148 suggestive genetic loci. However, the molecular mechanisms through which they contribute to CAD and the clinical impli...
Genome-Wide Association Study Humans Protein Interaction Maps Neural Networks, Computer Gene Regulatory Networks Phenotype Mice Genomics Computer Simulation Animals Gene Expression Profiling Case-Control Studies Coronary Artery Disease STAT3 Transcription Factor Genetic Loci Gene Expression Regulation Lumican Genetic Predisposition to Disease Computational Biology Signal Transduction Databases, Genetic Bayes Theorem
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Predicting transcription factor site occupancy using DNA sequence intrinsic and cell-type specific chromatin features.

BMC bioinformatics Jan 11, 2016
BACKGROUND: Understanding the mechanisms by which transcription factors (TF) are recruited to their physiological target sites is crucial for understanding gene regulation. DNA sequence intrinsic features such as predicted binding affinity are often ...
Histones Transcription Factors Humans Chromatin Immunoprecipitation Binding Sites Protein Processing, Post-Translational Machine Learning Nucleosomes Cell Lineage DNA Algorithms Chromatin Gene Expression Regulation Genome, Human
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Effect of Short-Term Stimulation with Interleukin-1β and Differentiation Medium on Human Mesenchymal Stromal Cell Paracrine Activity in Coculture with Osteoblasts.

BioMed research international Dec 22, 2015
INTRODUCTION: Human mesenchymal stromal cells (hMSCs) exhibit the potential to accelerate bone healing by enhanced osteogenic differentiation. Interleukin-1β is highly expressed during fracture healing and has been demonstrated to exert a significant...
Culture Media Osteosarcoma Cell Differentiation Interleukin-1beta Paracrine Communication Male Mesenchymal Stem Cells Humans Osteogenesis Female Coculture Techniques Middle Aged Adult Gene Expression Regulation Time Factors Osteoblasts Cell Line, Tumor
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Alterations in bone morphogenetic protein 15, growth differentiation factor 9, and gene expression in granulosa cells in preovulatory follicles of dairy cows given porcine LH.

Theriogenology Dec 20, 2015
In a previous work, using porcine LH (pLH) in lieu of GnRH for synchronizing ovulation in dairy cows improved pregnancy rates without increasing plasma progesterone concentrations after ovulation. The LH profile is known to remain elevated above basa...
Gene Expression Regulation Ovarian Follicle Bone Morphogenetic Protein 15 Growth Differentiation Factor 9 Granulosa Cells Gonadotropin-Releasing Hormone Luteinizing Hormone Female Follicular Fluid Animals Swine Cattle
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Label-free and dynamic evaluation of cell-surface epidermal growth factor receptor expression via an electrochemiluminescence cytosensor.

Talanta Dec 18, 2015
A label-free electrochemiluminescence (ECL) cytosensor was developed for dynamically evaluating of epidermal growth factor receptor (EGFR) expression on MCF-7 cancer cells based on the specific recognition of epidermal growth factor (EGF) with its re...
Sulfides ErbB Receptors Gold Humans Gene Expression Regulation Metal Nanoparticles Epidermal Growth Factor Biosensing Techniques Electrochemistry Luminescent Measurements MCF-7 Cells Optical Imaging Cadmium Compounds Quantum Dots Flow Cytometry
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The Effect of Leonurus sibiricus Plant Extracts on Stimulating Repair and Protective Activity against Oxidative DNA Damage in CHO Cells and Content of Phenolic Compounds.

Oxidative medicine and cellular longevity Dec 14, 2015
Leonurus sibiricus L. has been used as a traditional and medicinal herb for many years in Asia and Europe. This species is known to have antibacterial, anti-inflammatory, and antioxidant activity and has demonstrated a reduction of intracellular reac...
Antioxidants Plant Extracts Wound Healing Cell Survival Protective Agents Phenols CHO Cells Cricetulus Oxidation-Reduction Leonurus Animals Gene Expression Regulation Cytoprotection Cricetinae DNA Breaks, Double-Stranded DNA Damage DNA Repair Chromatography, High Pressure Liquid Regeneration Spectrometry, Mass, Electrospray Ionization
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LedPred: an R/bioconductor package to predict regulatory sequences using support vector machines.

Bioinformatics (Oxford, England) Dec 1, 2015
UNLABELLED: Supervised classification based on support vector machines (SVMs) has successfully been used for the prediction of cis-regulatory modules (CRMs). However, no integrated tool using such heterogeneous data as position-specific scoring matri...
Metabolic Networks and Pathways Gene Expression Regulation Molecular Sequence Annotation Computer Graphics Systems Integration Software Animals Mice Support Vector Machine Drosophila
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Microarray expression profiling and gene ontology analysis of long non-coding RNAs in spontaneously hypertensive rats and their potential roles in the pathogenesis of hypertension.

Molecular medicine reports Nov 11, 2015
Long non-coding RNAs (lncRNAs) have been demonstrated to be significant in numerous biological processes. Hypertension is a form of cardiovascular disease with at least one billion cases worldwide. The present study sought to compare the differential...
Down-Regulation Gene Ontology Oligonucleotide Array Sequence Analysis Rats, Inbred SHR Rats, Inbred WKY Real-Time Polymerase Chain Reaction Hypertension RNA, Long Noncoding Gene Expression Regulation Reproducibility of Results Animals Gene Expression Profiling
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Follicle-stimulating hormone-induced rescue of cumulus cell apoptosis and enhanced development ability of buffalo oocytes.

Domestic animal endocrinology Oct 31, 2015
The effect of follicle-stimulating hormone (FSH) on apoptotic status of cumulus cells, expression of proapoptotic and antiapoptotic genes, and development rate of in vitro fertilization-produced buffalo embryos were investigated. FSH supplementation ...
Gene Expression Regulation In Vitro Oocyte Maturation Techniques Cumulus Cells Embryo Culture Techniques Female Animals Apoptosis Dose-Response Relationship, Drug DNA Fragmentation Follicle Stimulating Hormone Oocytes Buffaloes
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Changes in brain ribonuclease (BRB) messenger RNA in granulosa cells (GCs) of dominant vs subordinate ovarian follicles of cattle and the regulation of BRB gene expression in bovine GCs.

Domestic animal endocrinology Oct 31, 2015
Brain ribonuclease (BRB) is a member of the ribonuclease A superfamily that is constitutively expressed in a range of tissues and is the functional homolog of human ribonuclease 1. This study was designed to characterize BRB gene expression in granul...
Brain Female Animals Cattle Estradiol RNA, Messenger Progesterone Granulosa Cells Gene Expression Regulation Ovulation Ribonucleases
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