AIMC Topic: Lipid Metabolism
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Integrated multi-omics analysis identifies lipid metabolism biomarkers in ONFH and reveals therapeutic potential of retinoic acid.
Scientific reports
Aug 21, 2025
Osteonecrosis of the femoral head (ONFH) is a debilitating condition frequently associated with dysregulation in lipid metabolism. The objective of this study was to identify potential biomarkers for ONFH through various analytical methods and experi...
Machine learning-assisted MALDI-MSI to characterize hippocampal subregion lipid and purine metabolic alterations in depression-related dry eye disease.
Analytical methods : advancing methods and applications
Aug 21, 2025
Dry eye disease (DED) and depression exhibit high comorbidity, yet lipid and purine diagnostic biomarkers for depression-related DED remain unidentified. In this study, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI)...
A lipid metabolism-related gene signature predicts prognosis after tamoxifen treatment in ER + breast cancer and reflects tumor microenvironment heterogeneity through single-cell analysis.
BMC medical genomics
Jul 31, 2025
BACKGROUND: Although the clinical outcome of ER + breast cancer patients receiving tamoxifen after surgery is favorable, a proportion of patients experience recurrence or death due to disease progression.
Advances in mass spectrometry of lipids for the investigation of Niemann-pick type C disease.
Lipids in health and disease
Jul 30, 2025
Niemann-Pick type C (NPC) disease is a devastating, fatal, neurodegenerative disease and a form of lysosomal storage disorder. It is caused by mutations in either NPC1 or NPC2 genes, leading to the accumulation of cholesterol and other lipids in the ...
Integrative transcriptomics and metabolomics reveal neuroendocrine-lipid crosstalk and adenosine signaling in broiler under heat stress.
BMC genomics
Jul 29, 2025
BACKGROUND: Heat stress (HS) is a significant challenge in poultry, negatively impacting feed efficiency and survival. These adaptive responses could lead to disrupted lipid metabolism, impaired immunity, and neural damage. We hypothesized that the n...
Machine learning identifies lipid-associated genes and constructs diagnostic and prognostic models for idiopathic pulmonary fibrosis.
Orphanet journal of rare diseases
Jul 10, 2025
OBJECTIVE: Emerging evidence suggests a potential relationship between lipid metabolism and idiopathic pulmonary fibrosis (IPF). This study aimed to identify lipid-related genes implicated in IPF pathogenesis.
Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis.
Journal of nanobiotechnology
Jul 5, 2025
BACKGROUND: Osteoarthritis (OA), the most prevalent joint disorder, is characterized by a complex etiology and a lack of safe and effective therapeutic interventions. Emerging evidence suggests that immune cell dysregulation plays a pivotal role in t...
Sperm metabolomic signatures of asthenozoospermia and teratozoospermia in Chinese reproductive-age men.
Scientific reports
Jul 4, 2025
Asthenozoospermia and teratozoospermia are common causes of male infertility. Despite their prevalence, the underlying metabolic mechanisms remain poorly understood. In this study, we conducted targeted metabolomic profiling of sperm samples from 131...
Identification of pyroptosis related genes and subtypes in atherosclerosis using multiomic and single cell analysis.
Scientific reports
Jul 1, 2025
Atherosclerosis (AS), the leading cause of cardiovascular diseases, is a chronic inflammatory disorder involving lipid metabolism, immune dysregulation, and cell death. Pyroptosis, a form of inflammatory programmed cell death, is implicated in AS pro...
Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk.
JCI insight
Jun 23, 2025
BACKGROUNDObesity, a growing health concern, often leads to metabolic disturbances, systemic inflammation, and vascular dysfunction. Emerging evidence suggests that adipose tissue-derived extracellular vesicles (adiposomes) may propagate obesity-rela...
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