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Mice, Inbred C57BL

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A Robotic System for Adaptive Training and Function Assessment of Forelimb Retraction in Mice.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society Aug 8, 2018
Rodent models are decisive for translational research in healthy and pathological conditions of motor function thanks to specific similarities with humans. Here, we present an upgraded version of the M-Platform, a robotic device previously designed t...
Animals Male Mice Mice, Inbred C57BL Female Biomechanical Phenomena Stroke Rehabilitation Friction Robotics Conditioning, Operant Forelimb Psychomotor Performance Cerebral Cortex Isometric Contraction
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A Novel Morphological Marker for the Analysis of Molecular Activities at the Single-cell Level.

Cell structure and function Jun 29, 2018
For more than a century, hematoxylin and eosin (H&E) staining has been the de facto standard for histological studies. Consequently, the legacy of histological knowledge is largely based on H&E staining. Due to the recent advent of multi-photon excit...
MAP Kinase Signaling System Single-Cell Analysis Mice, Transgenic Imaging, Three-Dimensional Machine Learning Microscopy, Fluorescence Biosensing Techniques Animals Dogs Mice, Inbred C57BL Madin Darby Canine Kidney Cells Fluorescence Resonance Energy Transfer
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Cell dynamic morphology classification using deep convolutional neural networks.

Cytometry. Part A : the journal of the International Society for Analytical Cytology May 15, 2018
Cell morphology is often used as a proxy measurement of cell status to understand cell physiology. Hence, interpretation of cell dynamic morphology is a meaningful task in biomedical research. Inspired by the recent success of deep learning, we here ...
Neural Networks, Computer Databases, Factual Animals Male Mice, Inbred C57BL Deep Learning Lymphocytes Mice Mice, Inbred BALB C
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Recognition of early stage thigmotaxis in Morris water maze test with convolutional neural network.

PloS one May 3, 2018
The Morris water maze test (MWM) is a useful tool to evaluate rodents' spatial learning and memory, but the outcome is susceptible to various experimental conditions. Thigmotaxis is a commonly observed behavioral pattern which is thought to be relate...
Reaction Time Swimming Carotid Artery, Common Maze Learning Carotid Stenosis Spatial Memory Taxis Response Animals Male Mice Mice, Inbred C57BL Neural Networks, Computer Machine Learning Sensitivity and Specificity
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Computational Analysis of Cell Dynamics in Videos with Hierarchical-Pooled Deep-Convolutional Features.

Journal of computational biology : a journal of computational molecular cell biology Apr 25, 2018
Computational analysis of cellular appearance and its dynamics is used to investigate physiological properties of cells in biomedical research. In consideration of the great success of deep learning in video analysis, we first introduce two-stream co...
Computational Biology Mice, Inbred BALB C Mice, Inbred C57BL Skin Diseases Algorithms Animals Male Mice Lymphocytes Video Recording Skin Transplantation Cell Physiological Phenomena Neural Networks, Computer
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Cortical frequency-specific plasticity is independently induced by intracortical circuitry.

Neuroscience letters Dec 21, 2017
Auditory learning induces frequency-specific plasticity in the auditory cortex. Both the auditory cortex and thalamus are involved in the cortical plasticity; however, the precise role of the intracortical circuity remains unclear until the contribut...
Lidocaine Neurons Acoustic Stimulation Auditory Cortex Neuronal Plasticity Action Potentials Evoked Potentials, Auditory Animals Mice, Inbred C57BL Electric Stimulation Mice Thalamus Voltage-Gated Sodium Channel Blockers
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Fully automated, deep learning segmentation of oxygen-induced retinopathy images.

JCI insight Dec 21, 2017
Oxygen-induced retinopathy (OIR) is a widely used model to study ischemia-driven neovascularization (NV) in the retina and to serve in proof-of-concept studies in evaluating antiangiogenic drugs for ocular, as well as nonocular, diseases. The primary...
Algorithms Female Animals Male Deep Learning Observer Variation Image Processing, Computer-Assisted Mice, Transgenic Retinal Neovascularization Microscopy, Confocal Disease Models, Animal Mice, Inbred C57BL Oxygen
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Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor κB ligand-induced NF-κB pathway.

Biochemical and biophysical research communications Dec 18, 2017
Linarin, a natural flavonoid glycoside widely found in plants, has been reported to possess anti-inflammation, neuroprotection and osteogenic properties. However, its impact on osteoclast remains unclear. In the present study, the effects of linarin ...
Osteoblasts Glycosides Dose-Response Relationship, Drug NF-kappa B Osteogenesis Cells, Cultured RAW 264.7 Cells Macrophages Signal Transduction Animals RANK Ligand Mice Mice, Inbred C57BL
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Kaempferol modulates Angiopoietin-like protein 2 expression to lessen the mastitis in mice.

Pharmacological reports : PR Nov 22, 2017
BACKGROUND: Mastitis is inflammation of a breast (or udder). Angiopoietin-like protein 2 (ANGPTL2) has been found as a key inflammatory mediator in mastitis. Purpose of this research was to investigate the mechanisms about repressing effect of kaempf...
Mice, Inbred C57BL Animals Angiopoietin-Like Protein 2 Epithelial Cells Mice Tumor Necrosis Factor-alpha Kaempferols Peroxidase Mastitis Interleukin-6 Angiopoietin-like Proteins Inflammation Female
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Sparse Supervised Classification Methods Predict and Characterize Nanomaterial Exposures: Independent Markers of MWCNT Exposures.

Toxicologic pathology Sep 22, 2017
Recent experimental evidence indicates significant pulmonary toxicity of multiwalled carbon nanotubes (MWCNTs), such as inflammation, interstitial fibrosis, granuloma formation, and carcinogenicity. Although numerous studies explored the adverse pote...
Animals Male Lung Mice Biomarkers Support Vector Machine Mice, Inbred C57BL Nanotubes, Carbon Bronchoalveolar Lavage Fluid
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