BACKGROUND: Intervertebral disc degeneration (IVDD) is a primary cause of chronic low back pain, significantly impacting quality of life and healthcare systems globally. Despite its prevalence, the molecular mechanisms underlying IVDD remain unclear,...
International journal of biological macromolecules
Sep 1, 2025
Protein lactylation plays a critical regulatory role in various human diseases; however, its function in recurrent spontaneous abortion (RSA) remains unclear. In this study, we integrated scRNA-seq (GSE214607), bulk RNA-seq (GSE26787 and GSE165004) d...
PURPOSE OF REVIEW: Interstitial lung disease (ILD) presents significant diagnostic and therapeutic challenges due to underlying biological heterogeneity and variable clinical course. Traditional diagnostic and prognostic tools are limited in their ab...
Inflammatory responses play a crucial role in the progression of pediatric neurogenic bladder (NB)-associated fibrosis; however, their specific contributions remain poorly understood. This study aimed to identify inflammation-related biomarkers for d...
AIM: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) are closely intertwined comorbidities that present significant clinical challenges due to the poorly understood pathophysiological mechanisms driving their coexistence. In this ...
Ferroptosis and lethal sepsis are interlinked, although this association remains largely unknown to clinical panels. Sepsis is characterized by dysfunction of the inflammatory microenvironment. Most septic biomarkers lack independent validation, and ...
BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the CNS characterized by a heterogeneous disease trajectory, highlighting the need for biomarkers to predict disease activity. Current disease-monitorin...
BACKGROUND: Functional magnetic resonance imaging (fMRI) is a powerful tool for non-invasive evaluation of micro-changes in the kidneys. This study aims to develop classification and prognostic models based on multi-modal data.
Overtraining syndrome (OTS) poses a critical challenge in youth soccer, particularly during periods of rapid physiological maturation combined with high training demands. This study aimed to develop and validate a multidimensional prediction model fo...
PURPOSE: Primary aldosteronism (PA) is prevalent among hypertensive patients, and associated with worsened cardiovascular outcomes compared to essential hypertension (HT). Screening and diagnostics for PA are currently complicated and invasive, why n...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.