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Dose-Response Relationship, Drug

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Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences.

Turkish journal of medical sciences Jan 1, 2015
BACKGROUND/AIM: Treating animals repeatedly with intermittent and increasing morphine doses has been suggested to allow some withdrawal during each dosing interval, which causes repeated stress. The present study aimed to test this hypothesis and ass...
Female Animals Male Rats, Wistar Mice, Inbred BALB C Dose-Response Relationship, Drug Analgesics Analgesics, Opioid Morphine Sex Factors Drug Administration Schedule Clonidine Grooming Mice, Inbred Strains Naloxone Narcotic Antagonists Substance Withdrawal Syndrome
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Compressed images for affinity prediction-2 (CIFAP-2): an improved machine learning methodology on protein-ligand interactions based on a study on caspase 3 inhibitors.

Journal of enzyme inhibition and medicinal chemistry Jan 1, 2015
The aim of this study is to propose an improved computational methodology, which is called Compressed Images for Affinity Prediction-2 (CIFAP-2) to predict binding affinities of structurally related protein-ligand complexes. CIFAP-2 method is establi...
Humans Machine Learning Dose-Response Relationship, Drug Caspase 3 Regression Analysis Structure-Activity Relationship Molecular Structure Sulfonamides Ligands Enzyme Inhibitors
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