AIMC Topic: Mice, Inbred C57BL

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Icariin improves eNOS/NO pathway to prohibit the atherogenesis of apolipoprotein E-null mice.

Canadian journal of physiology and pharmacology Dec 22, 2016
Impaired endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) pathway induces atherogenesis. The present study examined whether icariin improves the eNOS/NO pathway to prohibit the atherogenesis of apolipoprotein E-null (ApoE) mice. In vitro, p...
Apolipoproteins E Gene Deletion Nitric Oxide Synthase Type III Mice, Inbred C57BL Humans Flavonoids Animals Atherosclerosis Mice Gene Expression Regulation, Enzymologic Nitric Oxide
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Uncertainty Quantification of Oscillation Suppression During DBS in a Coupled Finite Element and Network Model.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society Sep 13, 2016
Models of the cortico-basal ganglia network and volume conductor models of the brain can provide insight into the mechanisms of action of deep brain stimulation (DBS). In this study, the coupling of a network model, under parkinsonian conditions, to ...
Basal Ganglia Subthalamic Nucleus Stochastic Processes Finite Element Analysis Uncertainty Electrodes, Implanted Computer Simulation Animals Mice Models, Neurological Mice, Inbred C57BL Parkinson Disease Deep Brain Stimulation Nonlinear Dynamics Cerebral Cortex Neural Networks, Computer
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A neural network-based method for spectral distortion correction in photon counting x-ray CT.

Physics in medicine and biology Jul 29, 2016
Spectral CT using a photon counting x-ray detector (PCXD) shows great potential for measuring material composition based on energy dependent x-ray attenuation. Spectral CT is especially suited for imaging with K-edge contrast agents to address the ot...
Artifacts Phantoms, Imaging Photons Animals Mice Mice, Inbred C57BL Radiographic Image Interpretation, Computer-Assisted Neural Networks, Computer Algorithms Tomography, X-Ray Computed
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A neurorobotic platform for locomotor prosthetic development in rats and mice.

Journal of neural engineering Feb 10, 2016
OBJECTIVES: We aimed to develop a robotic interface capable of providing finely-tuned, multidirectional trunk assistance adjusted in real-time during unconstrained locomotion in rats and mice.
Equipment Design Hindlimb Locomotion Animals Spinal Cord Injuries Mice Female Rats Rats, Inbred Lew Mice, Inbred C57BL Neural Prostheses Robotics
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Heat shock protein A12B protects against sepsis-induced impairment in vascular endothelial permeability.

The Journal of surgical research Dec 30, 2015
BACKGROUND: As a common and life-threatening infectious syndrome, sepsis contributes significantly to morbidity and mortality in clinical settings. Vascular endothelial injury and hyperpermeability play an important role in the development of sepsis-...
Blotting, Western Human Umbilical Vein Endothelial Cells Permeability Up-Regulation Endothelium, Vascular Mice Escherichia coli HSP70 Heat-Shock Proteins Lipopolysaccharides Humans Mice, Inbred C57BL Biomarkers Animals Male Sepsis Real-Time Polymerase Chain Reaction
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Automated measurement of mouse social behaviors using depth sensing, video tracking, and machine learning.

Proceedings of the National Academy of Sciences of the United States of America Sep 9, 2015
A lack of automated, quantitative, and accurate assessment of social behaviors in mammalian animal models has limited progress toward understanding mechanisms underlying social interactions and their disorders such as autism. Here we present a new in...
Animals Male Image Processing, Computer-Assisted Mice Mice, Inbred BALB C Mice, Inbred C57BL Video Recording Observer Variation Pattern Recognition, Automated Algorithms Computers Female Reproducibility of Results Machine Learning Software Models, Animal Behavior, Animal Social Behavior
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Innovative application of confocal Raman spectroscopy and Machine learning in cardiovascular diseases identification.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Nov 5, 2025
Myocardial hypertrophy and heart failure are leading causes of mortality in cardiovascular diseases, yet current diagnostic techniques lack the resolution to monitor molecular changes effectively. In this study, we employed confocal Raman spectroscop...
Cardiovascular Diseases Mice Spectrum Analysis, Raman Myocardium Disease Models, Animal Mice, Inbred C57BL Heart Failure Machine Learning Animals Male
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Decoding chronic stress: From behavioral-molecular dynamics in mice to clinical implications of cortisol and IL-17 in depression severity.

Journal of affective disorders Sep 15, 2025
BACKGROUNDS: The etiology of depression involves chronic stress, a recognized determinant of onset and severity. This study adopts a translational approach, utilizing a mouse model and a clinical cohort to explore the relationship between chronic str...
Hydrocortisone Middle Aged Severity of Illness Index Depression Stress, Psychological Interleukin-17 Mice Disease Models, Animal Mice, Inbred C57BL Chronic Disease Female Adult Animals Male Humans Machine Learning Biomarkers
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Call category classification of the isolation-induced ultrasonic vocalizations emitted by BTBR TItpr3/J mouse pups exposed to different perinatal diets.

Brain research Sep 1, 2025
Autism spectrum disorder (ASD) is characterized by deficits in social communication and repetitive behaviors/restricted interests that may be diagnosed as early as 2 years of age. This suggests that the pathology underlying the disorder is present du...
Autism Spectrum Disorder Pregnancy Female Mice, Inbred C57BL Diet, High-Fat Social Isolation Animals, Newborn Prenatal Exposure Delayed Effects Animals Male Mice Disease Models, Animal Vocalization, Animal
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CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH.

Free radical biology & medicine Aug 16, 2025
Metabolic dysfunction-associated steatohepatitis (MASH) is a complex liver disease whose pathogenesis involving endoplasmic reticulum (ER) stress and ferroptosis. However, key regulatory genes remain poorly understood, hindering the development of ef...
Mice Fatty Liver Disease Models, Animal Hep G2 Cells Cyclin-Dependent Kinase Inhibitor p21 Humans Animals Male Non-alcoholic Fatty Liver Disease Gene Expression Regulation Endoplasmic Reticulum Stress Phenylenediamines Early Growth Response Protein 1 Mice, Inbred C57BL Liver Diet, High-Fat Ferroptosis
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