AIMC Topic: Rats, Sprague-Dawley

Clear Filters Showing 91 to 100 of 184 articles

A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome.

Nutrients Dec 22, 2017
Since coffee may help to prevent the development of metabolic syndrome (MetS), we aimed to evaluate the short- and long-term effects of a coffee-based supplement on different features of diet-induced MetS. In this study, 24 Sprague Dawley rats were d...
Time Factors Insulin Resistance Seeds Rats, Sprague-Dawley Disease Models, Animal Metabolic Syndrome Dietary Supplements Liver Diet, High-Fat Lipids Cytokines Animals Blood Glucose Insulin Caffeic Acids Coffea Carbon-13 Magnetic Resonance Spectroscopy Non-alcoholic Fatty Liver Disease Dietary Sucrose Alkaloids Diterpenes
View on PubMed DOI

Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model.

Drug design, development and therapy Dec 21, 2017
OBJECTIVES: A knee joint contracture, a loss in passive range of motion (ROM), can be caused by prolonged immobility. In a rat knee immobilization flexion contracture model, the posterior capsule was shown to contribute to an irreversible limitation ...
Biomechanical Phenomena Joints Animals Collagen Type III Collagenases Contracture Range of Motion, Articular Hindlimb Suspension Injections, Intra-Articular Joint Capsule Collagen Type I Male Proteolysis Time Factors Rats, Sprague-Dawley Disease Models, Animal Recovery of Function
View on PubMed DOI

Identification and characterization of the structure-activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum.

Scientific reports Dec 20, 2017
The adverse effects of Polygonum (P.) multiflorum, including abnormal bilirubin metabolism, are a serious public health issue. As uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) is the only enzyme responsible for bilirubin metabolism, ...
Fallopia multiflora Glucuronosyltransferase In Vitro Techniques Animals Plant Extracts Male Rats Plant Roots Chromatography, High Pressure Liquid Rats, Sprague-Dawley Microsomes, Liver Structure-Activity Relationship Anthraquinones Glycosides
View on PubMed DOI

Development and validation of an LC-MS/MS method for quantification of NC-8 in rat plasma and its application to pharmacokinetic studies.

Journal of food and drug analysis Nov 11, 2017
ent-16-Oxobeyeran-19-N-methylureido (NC-8) is a recently synthesized derivative of isosteviol that showed anti-hepatitis B virus (HBV) activity by disturbing replication and gene expression of the HBV and by inhibiting the host toll-like receptor 2/n...
Tandem Mass Spectrometry Drug Stability Diterpenes, Kaurane Rats Rats, Sprague-Dawley Chromatography, Liquid Molecular Structure Reproducibility of Results Animals Antiviral Agents Hepatitis B virus
View on PubMed DOI

Pharmacokinetics, bioavailability, tissue distribution and excretion of tangeretin in rat.

Journal of food and drug analysis Sep 22, 2017
Tangeretin, 4',5,6,7,8-pentamethoxyflavone, is one of the major polymethoxyflavones (PMFs) existing in citrus fruits, particularly in the peels of sweet oranges and mandarins. Tangeretin has been reported to possess several beneficial bioactivities i...
Biological Availability Gastrointestinal Tract Tissue Distribution Animals Citrus Rats Male Flavones Rats, Sprague-Dawley Feces Liver Plant Extracts Fruit Administration, Oral
View on PubMed DOI

Development of a highly sensitive and specific ELISA method for the determination of l-corydalmine in SD rats with monoclonal antibody.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Sep 14, 2017
l-Corydalmine (l-CDL) is a potent analgesic constituent of the traditional Chinese medicine, Rhizoma Corydalis. However, the pharmacokinetic process and tissue distribution of l-CDL in vivo are still unknown. Therefore, it is necessary to establish a...
Limit of Detection Myocardium Rats Berberine Tissue Distribution Reproducibility of Results Chromatography, High Pressure Liquid Enzyme-Linked Immunosorbent Assay Animals Linear Models Rats, Sprague-Dawley Liver Antibodies, Monoclonal
View on PubMed DOI

Robot-Applied Resistance Augments the Effects of Body Weight-Supported Treadmill Training on Stepping and Synaptic Plasticity in a Rodent Model of Spinal Cord Injury.

Neurorehabilitation and neural repair Jul 25, 2017
BACKGROUND: The application of resistive forces has been used during body weight-supported treadmill training (BWSTT) to improve walking function after spinal cord injury (SCI). Whether this form of training actually augments the effects of BWSTT is ...
Female Animals Neuronal Plasticity Rats, Sprague-Dawley Disease Models, Animal Hindlimb Synaptophysin Spinal Cord Injuries Oleanolic Acid Motor Activity Recovery of Function Robotics Exercise Therapy Saponins Spinal Cord
View on PubMed DOI

Metabolic changes in rat serum after administration of suberoylanilide hydroxamic acid and discriminated by SVM.

Human & experimental toxicology Jan 13, 2017
Suberoylanilide hydroxamic acid (SAHA) exerts marked anticancer effects via promotion of apoptosis, cell cycle arrest, and prevention of oncogene expression. In this study, serum metabolomics and artificial intelligence recognition were used to inves...
Animals Dose-Response Relationship, Drug Rats Random Allocation Support Vector Machine Hydroxamic Acids Rats, Sprague-Dawley Vorinostat Metabolomics
View on PubMed DOI

Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro.

The Kaohsiung journal of medical sciences Dec 30, 2016
Achyranthes bidentate Blume (Niuxi) is often employed for treatment of arthritis in Traditional Chinese Medicine and possesses anti-inflammatory properties. Phytochemical and pharmacological studies proved the oleanane-type saponins to be the main bi...
Caspase 3 Anti-Inflammatory Agents, Non-Steroidal Plant Roots Interleukin-1beta NF-kappa B Gene Expression Regulation Matrix Metalloproteinase 9 Inflammation Animals Proliferating Cell Nuclear Antigen Primary Cell Culture bcl-2-Associated X Protein Signal Transduction Cyclooxygenase 2 Male Achyranthes Chondrocytes Rats, Sprague-Dawley Cartilage, Articular Plant Extracts bcl-Associated Death Protein Saponins Apoptosis Matrix Metalloproteinase 3 Rats bcl-X Protein Tumor Suppressor Protein p53
View on PubMed DOI

Simultaneous determination of imperatorin and its metabolite xanthotoxol in rat plasma and urine by LC-MS/MS and its application to pharmacokinetic studies.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Dec 28, 2016
An accurate, precise, selective, and sensitive liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of imperatorin (IMP) and its metabolite, xanthotoxol (XAN), in rat plasma and ...
Chromatography, Liquid Reproducibility of Results Limit of Detection Tandem Mass Spectrometry Animals Linear Models Male Furocoumarins Rats Rats, Sprague-Dawley
View on PubMed DOI
Popular Topics
Recent Journals