AIMC Topic: Antineoplastic Agents

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A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia.

Nature communications Jan 3, 2018
Cancers that appear pathologically similar often respond differently to the same drug regimens. Methods to better match patients to drugs are in high demand. We demonstrate a promising approach to identify robust molecular markers for targeted treatm...
Humans Machine Learning Algorithms Precision Medicine Biomarkers, Tumor Cell Line Datasets as Topic Drug Resistance, Neoplasm Etoposide Topoisomerase II Inhibitors Leukemia, Myeloid, Acute Antineoplastic Agents DNA Helicases Nuclear Proteins Transcription Factors
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Cytotoxicity of the Defensive Secretion from the Medicinal Insect Blaps rynchopetera.

Molecules (Basel, Switzerland) Dec 21, 2017
Fairmaire has long been used as a folk medicine by the Yi and Bai ethnic groups in China to treat fever, cough, gastritis, boils, and tumors. In the present study, the cytotoxicity of the defensive secretion (TDS) of against AGS Caco-2, HepG2 U251 ...
Antineoplastic Agents Cell Line, Tumor Cell Survival Molecular Structure Volatile Organic Compounds Humans Animals Coleoptera Alkenes Hydroquinones Cyclohexenes Benzoquinones Bodily Secretions
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Rate and association of lower urinary tract infection with recurrence after transurethral resection of bladder tumor.

Investigative and clinical urology Dec 15, 2017
PURPOSE: To evaluate the rate of pyuria and bacteriuria after transurethral resection of bladder tumor (TURBT).
Pyuria Bacteriuria Urinary Tract Infections Neoplasm Recurrence, Local Administration, Intravesical Postoperative Complications Chemotherapy, Adjuvant Antineoplastic Agents Humans Follow-Up Studies Retrospective Studies Risk Factors Urinary Bladder Neoplasms Female Aged Aged, 80 and over Male Middle Aged
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Salinomycin-loaded lipid-polymer nanoparticles with anti-CD20 aptamers selectively suppress human CD20+ melanoma stem cells.

Acta pharmacologica Sinica Dec 14, 2017
Melanoma is the deadliest type of skin cancer. CD20+ melanoma stem cells (CSCs) are pivotal for metastasis and initiation of melanoma. Therefore, selective elimination of CD20+ melanoma CSCs represents an effective treatment to eradicate melanoma. Sa...
Humans Melanoma Animals Antigens, CD20 Pyrans Particle Size Drug Carriers Antineoplastic Agents Polyethylene Glycols Aptamers, Nucleotide Lecithins Nanoparticles Xenograft Model Antitumor Assays Neoplastic Stem Cells Mice, Inbred BALB C
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Evaluation of Aristolochia indica L. and Piper nigrum L. methanol extract against centipede Scolopendra moristans L. using Wistar albino rats and screening of bioactive compounds by high pressure liquid chromatography: a polyherbal formulation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Nov 28, 2017
The present study was aimed to explore the anti-venom activity of Aristolochia indica and Piper nigrum plants against the centipede (Scolopendra moristans) envenomation in animal model. In vtiro phytochemical, antioxidant and blocking of proteolysis ...
Phytochemicals Mice Phytotherapy Methanol Piper nigrum Antioxidants Annelida Chromatography, High Pressure Liquid Proteolysis Humans Plant Extracts Antivenins Venoms Behavior, Animal Animals Aristolochia Rats, Wistar Toxicity Tests, Acute Antineoplastic Agents Lipids Electrolytes Cell Line, Tumor Organ Specificity
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From word models to executable models of signaling networks using automated assembly.

Molecular systems biology Nov 24, 2017
Word models (natural language descriptions of molecular mechanisms) are a common currency in spoken and written communication in biomedicine but are of limited use in predicting the behavior of complex biological networks. We present an approach to b...
Drug Resistance, Neoplasm Tumor Suppressor Protein p53 Proto-Oncogene Proteins p21(ras) Proto-Oncogene Proteins B-raf Vemurafenib Antineoplastic Agents Neural Networks, Computer Cell Line, Tumor Computer Simulation Gene Expression Regulation, Neoplastic Humans Language Natural Language Processing Models, Genetic Melanoma DNA Damage Signal Transduction Skin Neoplasms Sulfonamides Indoles Enzyme Inhibitors
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Commercial glucometer as signal transducer for simple evaluation of DNA methyltransferase activity and inhibitors screening.

Analytica chimica acta Nov 23, 2017
DNA methyltransferase (MTase) plays an important role in many biological processes and has been recognized as a predictive cancer biomarker far before other signs of malignancy and a therapeutic target in cancer treatment. Thus simple and sensitive d...
Enzyme Inhibitors Enzyme Assays DNA-Cytosine Methylases Humans Antineoplastic Agents Biosensing Techniques Signal Transduction DNA Methylation Limit of Detection Equipment Design Drug Evaluation, Preclinical Blood Glucose Self-Monitoring
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Selective cytotoxic and genotoxic activities of 5-(2-bromo-5-methoxybenzylidene)-thiazolidine-2,4-dione against NCI-H292 human lung carcinoma cells.

Pharmacological reports : PR Nov 22, 2017
BACKGROUND: Thiazolidine-2,4-dione ring system is used as a pharmacophore to build various heterocyclic compounds aimed to interact with biological targets. In the present study, benzylidene-2,4-thiazolidinedione derivatives (compounds 2-5) were synt...
Leukocytes, Mononuclear Antineoplastic Agents HL-60 Cells Cell Line, Tumor MCF-7 Cells Humans Lung Neoplasms K562 Cells DNA Fragmentation Apoptosis Thiazolidinediones Cytotoxins Comet Assay Mutagens
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Desert actinobacteria as a source of bioactive compounds production with a special emphases on Pyridine-2,5-diacetamide a new pyridine alkaloid produced by Streptomyces sp. DA3-7.

Microbiological research Nov 21, 2017
In the present study, 134 morphologically distinct actinobacteria isolates were obtained from soil samples from 10 different localities in the Saudi Arabian desert. The preliminary screening revealed that 16 of these isolates possessed antimicrobial ...
Soil Microbiology Salmonella typhimurium Pyridines MCF-7 Cells Enterococcus faecalis Alkaloids Cryptococcus neoformans Microbial Sensitivity Tests Cell Line, Tumor Adenocarcinoma Escherichia coli Streptomyces Female Desert Climate Breast Neoplasms Antineoplastic Agents Saudi Arabia Humans Anti-Infective Agents
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Open source machine-learning algorithms for the prediction of optimal cancer drug therapies.

PloS one Oct 26, 2017
Precision medicine is a rapidly growing area of modern medical science and open source machine-learning codes promise to be a critical component for the successful development of standardized and automated analysis of patient data. One important goal...
Humans Machine Learning Algorithms Precision Medicine Neoplasms Antineoplastic Agents Cell Line, Tumor Gene Expression
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