AIMC Topic: Dose-Response Relationship, Drug

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Antiviral activity of aconite alkaloids from Debx.

Natural product research Dec 22, 2017
Four diterpenoid alkaloids, namely, () hypaconitine, ) songorine, () mesaconitine and () aconitine, were isolated from the ethanol root extract of Debx. The antiviral activities of these alkaloids against tobacco mosaic virus (TMV) and cucumber mosa...
Aconitum Aconitine Cucumovirus Tobacco Mosaic Virus Dose-Response Relationship, Drug Plant Roots Molecular Structure Drug Evaluation, Preclinical Alkaloids Antiviral Agents
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Effect of Switching from Cilnidipine to Azelnidipine on Cardiac Sympathetic Nerve Function in Patients with Heart Failure Preserved Ejection Fraction.

International heart journal Dec 20, 2017
Cardiac sympathetic nerve activity is known to play a key role in the development and progression of heart failure (HF). Azelnidipine, an L-type calcium channel blocker (CCB), inhibits the sympathetic nerve activity of the central system. In contrast...
Heart Heart Failure Drug Substitution Calcium Channel Blockers Radionuclide Imaging Azetidinecarboxylic Acid Dihydropyridines Sympathetic Nervous System Middle Aged Treatment Outcome Follow-Up Studies Dose-Response Relationship, Drug Adult Humans Male Retrospective Studies Stroke Volume Female Echocardiography Aged Aged, 80 and over
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5-fluorouracil combined with cisplatin and mitomycin C as an optimized regimen for hyperthermic intraperitoneal chemotherapy in gastric cancer.

Journal of surgical oncology Dec 19, 2017
BACKGROUND AND OBJECTIVES: Optimized drug regimens for hyperthermic intraperitoneal chemotherapy (HIPEC) have not been standardized completely in patients with advanced gastric cancer (GC). We evaluated an optimized anti-tumor protocol comprising 5-f...
Stomach Neoplasms Cell Line, Tumor Antineoplastic Combined Chemotherapy Protocols Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Cell Growth Processes Cisplatin Fluorouracil Mitomycin Hyperthermia, Induced
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Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor κB ligand-induced NF-κB pathway.

Biochemical and biophysical research communications Dec 18, 2017
Linarin, a natural flavonoid glycoside widely found in plants, has been reported to possess anti-inflammation, neuroprotection and osteogenic properties. However, its impact on osteoclast remains unclear. In the present study, the effects of linarin ...
RANK Ligand Mice, Inbred C57BL Dose-Response Relationship, Drug NF-kappa B Osteogenesis Macrophages Animals Mice Signal Transduction RAW 264.7 Cells Osteoblasts Glycosides Cells, Cultured
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Incidence and Predictors of Postoperative Need for High-Dose Inotropic Support in Patients Undergoing Cardiac Surgery for Infective Endocarditis.

Journal of cardiothoracic and vascular anesthesia Dec 11, 2017
OBJECTIVE: Patients with infective endocarditis undergoing cardiac surgery are a high-risk population. Few data on incidence and predictors of need for high-dose inotropic support in this setting are currently available.
Endocarditis Cardiac Output, Low Cardiotonic Agents Retrospective Studies Time Factors Humans Intensive Care Units Follow-Up Studies Middle Aged Female Dose-Response Relationship, Drug Postoperative Complications Survival Rate Postoperative Care Hemodynamics Male Germany Incidence
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High-dose atorvastatin versus moderate dose on early vascular protection after ST-elevation myocardial infarction.

Drug design, development and therapy Dec 4, 2017
BACKGROUND AND AIM: Clinical benefits of early high-dose statin therapy after acute coronary syndromes are widely known; however, there is poor evidence on the specific setting of ST-elevation myocardial infarction (STEMI) and dose-dependent effects ...
Humans Prospective Studies Female Aged Aged, 80 and over Endothelium, Vascular Endothelial Cells Atorvastatin Anticholesteremic Agents Adolescent Inflammation Dose-Response Relationship, Drug Double-Blind Method ST Elevation Myocardial Infarction Young Adult Adult Male Middle Aged
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Novel cationic chitosan derivative bearing 1,2,3-triazolium and pyridinium: Synthesis, characterization, and antifungal property.

Carbohydrate polymers Nov 7, 2017
In this paper, novel cationic chitosan derivative possessing 1,2,3-triazolium and pyridinium groups was synthesized conveniently via cuprous-catalyzed azide-alkyne cycloaddition (CuAAC) and methylation. FTIR, H NMR, and elemental analysis examined th...
Triazoles Pyridinium Compounds Cations Structure-Activity Relationship Antifungal Agents Molecular Structure Fusarium Microbial Sensitivity Tests Dose-Response Relationship, Drug Chitosan
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Structural characterization and osteogenic bioactivity of a sulfated polysaccharide from pacific abalone (Haliotis discus hannai Ino).

Carbohydrate polymers Nov 6, 2017
Bone morphogenic protein-2 (BMP-2) is known to promote osteogenesis. To find novel adjuvants to enhance the activity of BMP-2, the present study investigated the structure BMP-2-induced osteogenic activity of a water-soluble polysaccharide from the g...
Cells, Cultured Molecular Structure Animals Polysaccharides Osteogenesis Mice Gastropoda Dose-Response Relationship, Drug Sulfates Bone Morphogenetic Protein 2
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Systematic evaluation of bioactive components and antioxidant capacity of some new and common bayberry cultivars using an in vitro gastrointestinal digestion method.

Food research international (Ottawa, Ont.) Oct 31, 2017
This study was aimed to investigate the impact of in vitro gastrointestinal digestion on some common and new bayberry cultivars. The contents of total phenolics (246-669mg gallic acid equivalents/kg FW (fresh weight)), flavonoids (116-689mg quercetin...
Gastric Acid Intestinal Secretions Principal Component Analysis Dose-Response Relationship, Drug Humans Ferric Compounds Reactive Oxygen Species Oxidation-Reduction Myrica Oxidative Stress Digestion Phenols Chromatography, High Pressure Liquid Antioxidants Benzothiazoles Caco-2 Cells Fruit Mass Spectrometry Sulfonic Acids Chlorides
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Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning.

Scientific reports Sep 29, 2017
In the last decade, high-content screening based on multivariate single-cell imaging has been proven effective in drug discovery to evaluate drug-induced phenotypic variations. Unfortunately, this method inherently requires fluorescent labeling which...
Humans Machine Learning Paclitaxel Microfluidics Image Processing, Computer-Assisted High-Throughput Screening Assays Dose-Response Relationship, Drug Cell Shape Antineoplastic Agents, Phytogenic Microscopy, Interference MCF-7 Cells
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