Sleep-wake states bidirectionally interact with epilepsy and seizures, but the mechanisms are unknown. A barrier to comprehensive characterization and the study of mechanisms has been the difficulty of annotating large chronic recording datasets. To ...
Studying locomotor activity in animal models is crucial for understanding physiological, behavioral, and pathological processes. This study aimed to develop an artificial intelligence-based tracking system called Goblotrop, designed to localize roden...
BACKGROUND: Obesity has emerged as a major global public health challenge and poses a significant threat to human health. Despite extensive research, the mechanisms underlying its pathological progression remain elusive.
The canonical framework for testing pain and mechanical sensitivity in rodents is manual delivery of stimuli to the paw. However, this approach is time-consuming, produces variability in results, requires significant training, and is ergonomically un...
Phytomedicine : international journal of phytotherapy and phytopharmacology
Oct 15, 2025
BACKGROUND: Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease with rising prevalence and limited therapies. Zhilining Formula (ZLN), a Traditional Chinese Medicine (TCM), shows clinical efficacy in UC, yet its core material b...
Stroke is a leading cause of long-term disability, frequently associated with persistent motor deficits. Gamma band oscillations, generated by synchronous discharge of parvalbumin-positive interneurons (PV-INs), are critically affected after stroke i...
: Perfluorooctane sulphonate (PFOS) is a persistent environmental contaminant with well-documented hepatotoxic properties. Nicotinamide, the amide derivative of vitamin B3, is widely utilized as a nutritional supplement and exerts multiple biological...
Type 2 diabetes mellitus (T2DM) is a severe metabolic disorder in which pancreatic injury plays a pivotal role in disease progression. Tanshinone IIA (TanIIA), a bioactive compound extracted from Salvia miltiorrhiza, has shown therapeutic potential i...
Statistical models are powerful tools for describing biological phenomena such as neuronal spiking activity. Although these models have been widely used to study spontaneous and stimulated neuronal activity, they have not yet been applied to analyze ...
The Journal of neuroscience : the official journal of the Society for Neuroscience
Oct 8, 2025
In temporal lobe epilepsy, interictal spikes (IS)-hyper-synchronous bursts of network activity-occur at high rates in between seizures. We sought to understand the influence of IS on working memory by recording hippocampal local field potentials from...
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