AIMC Topic: Angiogenesis Inhibitors

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Evaluating the impact of vitreomacular adhesion on anti-VEGF therapy for retinal vein occlusion using machine learning.

Scientific reports Jun 7, 2017
Vitreomacular adhesion (VMA) represents a prognostic biomarker in the management of exudative macular disease using anti-vascular endothelial growth factor (VEGF) agents. However, manual evaluation of VMA in 3D optical coherence tomography (OCT) is l...
Male Angiogenesis Inhibitors Treatment Outcome Visual Acuity Tomography, Optical Coherence Tissue Adhesions Vascular Endothelial Growth Factor A Macula Lutea Retinal Vein Occlusion Humans Machine Learning Female
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Machine Learning to Analyze the Prognostic Value of Current Imaging Biomarkers in Neovascular Age-Related Macular Degeneration.

Ophthalmology. Retina May 31, 2017
PURPOSE: To evaluate the potential of machine learning to predict best-corrected visual acuity (BCVA) outcomes from structural and functional assessments during the initiation phase in patients receiving standardized ranibizumab therapy for neovascul...
Fundus Oculi Vascular Endothelial Growth Factor A Intravitreal Injections Fluorescein Angiography Ranibizumab Humans Macula Lutea Retinal Pigment Epithelium Machine Learning Angiogenesis Inhibitors Wet Macular Degeneration Prospective Studies Treatment Outcome Prognosis Follow-Up Studies Reproducibility of Results Visual Acuity Tomography, Optical Coherence
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Preparation of arginine-glycine-aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization.

International journal of nanomedicine Dec 30, 2016
Neovascularization (NV) of the cornea can disrupt visual function, causing ocular diseases, including blindness. Therefore, treatment of corneal NV has a high public health impact. Epigalloccatechin-3-gallate (EGCG), presenting antiangiogenesis effec...
Human Umbilical Vein Endothelial Cells Ophthalmic Solutions Hyaluronic Acid Catechin Humans Integrin alphaVbeta3 Angiogenesis Inhibitors Animals Molecular Targeted Therapy Corneal Neovascularization Disease Models, Animal Nanoparticles Eye Burns Oligopeptides Mice, Inbred C57BL Cell Survival Burns, Chemical
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Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells.

Oxidative medicine and cellular longevity Dec 28, 2015
Hericium erinaceus (HE) is an edible mushroom that has been shown to exhibit anticancer and anti-inflammatory activities. We investigated the antiangiogenic and antioxidant potentials of ethanol extracts of HE in human endothelial (EA.hy926) cells up...
Glutathione Basidiomycota Endothelial Cells NF-E2-Related Factor 2 Angiogenesis Inducing Agents Antioxidants Anti-Inflammatory Agents Inflammation Matrix Metalloproteinase 9 Signal Transduction Intercellular Adhesion Molecule-1 Angiogenesis Inhibitors Humans Neovascularization, Pathologic Reactive Oxygen Species Tumor Necrosis Factor-alpha Heme Oxygenase-1 NF-kappa B
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Effect of imatinib on growth of experimental endometriosis in rats.

European journal of obstetrics, gynecology, and reproductive biology Dec 25, 2015
OBJECTIVE: Currently, medical and surgical treatment options for endometriosis are limited due to suboptimal efficacy, and also safety and tolerance issues. Long-term use of gonadotrophin-releasing hormone analogs, androgenes, and the danazol, which ...
Peritoneal Diseases Proto-Oncogene Proteins c-kit Rats Imatinib Mesylate Cell Proliferation Nitriles Angiogenesis Inhibitors Aromatase Inhibitors Endometrium Female Ovarian Follicle Disease Models, Animal Animals bcl-2-Associated X Protein Anastrozole Endometriosis Vascular Endothelial Growth Factor A Triazoles Transplantation, Autologous Peritoneum
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Monitoring vascular normalization induced by antiangiogenic treatment with (18)F-fluoromisonidazole-PET.

Molecular oncology Dec 22, 2015
BACKGROUND: Rationalization of antiangiogenics requires biomarkers. Vascular re-normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular...
Female Breast Neoplasms Animals Cell Line, Tumor Mice Angiogenesis Inhibitors Mice, Nude Pancreatic Neoplasms Breast Positron-Emission Tomography Quinolones Humans Neovascularization, Pathologic Antimetabolites, Antineoplastic Pancreas Deoxycytidine Gemcitabine Cell Hypoxia Misonidazole Fluorine Radioisotopes Benzimidazoles
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Drug repurposing to identify potential FDA-approved drugs targeting three main angiogenesis receptors through a deep learning framework.

Molecular diversity Aug 1, 2025
Tumor cell survival depends on the presence of oxygen and nutrients provided by existing blood vessels, particularly when cancer is in its early stage. Along with tumor growth in the vicinity of blood vessels, malignant cells require more nutrients; ...
United States Food and Drug Administration Humans Deep Learning Drug Approval United States ErbB Receptors Angiogenesis Inhibitors Receptors, Vascular Endothelial Growth Factor Drug Repositioning Receptors, Fibroblast Growth Factor Angiogenesis
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Deep learning-assisted analysis of biomarker changes after increase of dosing from aflibercept 2 mg to 8 mg in therapy-resistant neovascular age-related macular degeneration.

BMJ open ophthalmology Jun 1, 2025
PURPOSE: Age-related macular degeneration (AMD) remains the leading cause of blindness in developed countries. There are many different intravitreal anti-vascular endothelial growth factor (VEGF) drugs available for the treatment of neovascular AMD (...
Middle Aged Deep Learning Angiogenesis Inhibitors Treatment Outcome Follow-Up Studies Dose-Response Relationship, Drug Retrospective Studies Female Aged Aged, 80 and over Male Recombinant Fusion Proteins Wet Macular Degeneration Receptors, Vascular Endothelial Growth Factor Visual Acuity Tomography, Optical Coherence Vascular Endothelial Growth Factor A Intravitreal Injections Fluorescein Angiography Humans Biomarkers
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Predicting response to anti-VEGF therapy in neovascular age-related macular degeneration using random forest and SHAP algorithms.

Photodiagnosis and photodynamic therapy Jun 1, 2025
PURPOSE: This study aimed to establish and validate a prediction model based on machine learning methods and SHAP algorithm to predict response to anti-vascular endothelial growth factor (VEGF) therapy in neovascular age-related macular degeneration ...
Random Forest Vascular Endothelial Growth Factor A Macular Degeneration Photochemotherapy Wet Macular Degeneration Choroidal Neovascularization Aged, 80 and over Male Middle Aged Humans Angiogenesis Inhibitors Machine Learning Tomography, Optical Coherence Algorithms Retrospective Studies Female Aged
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GENERATIVE DEEP LEARNING APPROACH TO PREDICT POSTTREATMENT OPTICAL COHERENCE TOMOGRAPHY IMAGES OF AGE-RELATED MACULAR DEGENERATION AFTER 12 MONTHS.

Retina (Philadelphia, Pa.) Jun 1, 2025
PURPOSE: Predicting long-term anatomical responses in neovascular age-related macular degeneration patients is critical for patient-specific management. This study validates a generative deep learning model to predict 12-month posttreatment optical c...
Humans Retrospective Studies Female Intravitreal Injections Angiogenesis Inhibitors Aged Fluorescein Angiography Follow-Up Studies Aged, 80 and over Macula Lutea Visual Acuity Male Ranibizumab Tomography, Optical Coherence Deep Learning Wet Macular Degeneration Fundus Oculi Time Factors Vascular Endothelial Growth Factor A
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