AIMC Topic: Angiogenesis Inhibitors

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Preparation of arginine-glycine-aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization.

International journal of nanomedicine Dec 30, 2016
Neovascularization (NV) of the cornea can disrupt visual function, causing ocular diseases, including blindness. Therefore, treatment of corneal NV has a high public health impact. Epigalloccatechin-3-gallate (EGCG), presenting antiangiogenesis effec...
Catechin Mice, Inbred C57BL Humans Molecular Targeted Therapy Cell Survival Oligopeptides Animals Burns, Chemical Integrin alphaVbeta3 Nanoparticles Human Umbilical Vein Endothelial Cells Corneal Neovascularization Angiogenesis Inhibitors Ophthalmic Solutions Eye Burns Disease Models, Animal Hyaluronic Acid
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Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells.

Oxidative medicine and cellular longevity Dec 28, 2015
Hericium erinaceus (HE) is an edible mushroom that has been shown to exhibit anticancer and anti-inflammatory activities. We investigated the antiangiogenic and antioxidant potentials of ethanol extracts of HE in human endothelial (EA.hy926) cells up...
Neovascularization, Pathologic Heme Oxygenase-1 Glutathione Basidiomycota Humans Endothelial Cells Tumor Necrosis Factor-alpha NF-E2-Related Factor 2 Antioxidants Reactive Oxygen Species Inflammation NF-kappa B Signal Transduction Anti-Inflammatory Agents Angiogenesis Inhibitors Matrix Metalloproteinase 9 Intercellular Adhesion Molecule-1 Angiogenesis Inducing Agents
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Effect of imatinib on growth of experimental endometriosis in rats.

European journal of obstetrics, gynecology, and reproductive biology Dec 25, 2015
OBJECTIVE: Currently, medical and surgical treatment options for endometriosis are limited due to suboptimal efficacy, and also safety and tolerance issues. Long-term use of gonadotrophin-releasing hormone analogs, androgenes, and the danazol, which ...
Animals Rats Cell Proliferation Angiogenesis Inhibitors Endometrium Disease Models, Animal bcl-2-Associated X Protein Endometriosis Vascular Endothelial Growth Factor A Triazoles Transplantation, Autologous Peritoneum Female Proto-Oncogene Proteins c-kit Imatinib Mesylate Nitriles Aromatase Inhibitors Ovarian Follicle Anastrozole Peritoneal Diseases
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Monitoring vascular normalization induced by antiangiogenic treatment with (18)F-fluoromisonidazole-PET.

Molecular oncology Dec 22, 2015
BACKGROUND: Rationalization of antiangiogenics requires biomarkers. Vascular re-normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular...
Benzimidazoles Antimetabolites, Antineoplastic Deoxycytidine Gemcitabine Misonidazole Quinolones Neovascularization, Pathologic Pancreas Cell Hypoxia Fluorine Radioisotopes Mice Angiogenesis Inhibitors Mice, Nude Humans Pancreatic Neoplasms Female Breast Breast Neoplasms Positron-Emission Tomography Animals Cell Line, Tumor
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Deep learning-assisted analysis of biomarker changes after increase of dosing from aflibercept 2 mg to 8 mg in therapy-resistant neovascular age-related macular degeneration.

BMJ open ophthalmology Jun 1, 2025
PURPOSE: Age-related macular degeneration (AMD) remains the leading cause of blindness in developed countries. There are many different intravitreal anti-vascular endothelial growth factor (VEGF) drugs available for the treatment of neovascular AMD (...
Vascular Endothelial Growth Factor A Treatment Outcome Intravitreal Injections Follow-Up Studies Fluorescein Angiography Dose-Response Relationship, Drug Recombinant Fusion Proteins Visual Acuity Wet Macular Degeneration Tomography, Optical Coherence Receptors, Vascular Endothelial Growth Factor Humans Biomarkers Retrospective Studies Female Aged Aged, 80 and over Male Middle Aged Deep Learning Angiogenesis Inhibitors
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Predicting response to anti-VEGF therapy in neovascular age-related macular degeneration using random forest and SHAP algorithms.

Photodiagnosis and photodynamic therapy Jun 1, 2025
PURPOSE: This study aimed to establish and validate a prediction model based on machine learning methods and SHAP algorithm to predict response to anti-vascular endothelial growth factor (VEGF) therapy in neovascular age-related macular degeneration ...
Humans Machine Learning Algorithms Retrospective Studies Female Random Forest Vascular Endothelial Growth Factor A Macular Degeneration Photochemotherapy Wet Macular Degeneration Choroidal Neovascularization Aged Aged, 80 and over Male Middle Aged Angiogenesis Inhibitors Tomography, Optical Coherence
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GENERATIVE DEEP LEARNING APPROACH TO PREDICT POSTTREATMENT OPTICAL COHERENCE TOMOGRAPHY IMAGES OF AGE-RELATED MACULAR DEGENERATION AFTER 12 MONTHS.

Retina (Philadelphia, Pa.) Jun 1, 2025
PURPOSE: Predicting long-term anatomical responses in neovascular age-related macular degeneration patients is critical for patient-specific management. This study validates a generative deep learning model to predict 12-month posttreatment optical c...
Wet Macular Degeneration Fundus Oculi Vascular Endothelial Growth Factor A Intravitreal Injections Fluorescein Angiography Macula Lutea Ranibizumab Humans Retrospective Studies Female Aged Aged, 80 and over Male Deep Learning Time Factors Angiogenesis Inhibitors Follow-Up Studies Visual Acuity Tomography, Optical Coherence
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Prediction of prognosis of immune checkpoint inhibitors combined with anti-angiogenic agents for unresectable hepatocellular carcinoma by machine learning-based radiomics.

BMC cancer May 19, 2025
OBJECTIVES: This study aims to develop and validate a novel radiomics model utilizing magnetic resonance imaging (MRI) to predict progression-free survival (PFS) in patients with unresectable hepatocellular carcinoma (uHCC) who are receiving a combin...
Liver Neoplasms Carcinoma, Hepatocellular Immune Checkpoint Inhibitors Nomograms Angiogenesis Inhibitors Antineoplastic Combined Chemotherapy Protocols Aged Adult Radiomics Male Middle Aged Magnetic Resonance Imaging Progression-Free Survival Humans Machine Learning Prognosis Retrospective Studies Female
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Multi-Omics Integration With Machine Learning Identified Early Diabetic Retinopathy, Diabetic Macula Edema and Anti-VEGF Treatment Response.

Translational vision science & technology Dec 2, 2024
PURPOSE: Identify optimal metabolic features and pathways across diabetic retinopathy (DR) stages, develop risk models to differentiate diabetic macular edema (DME), and predict anti-vascular endothelial growth factor (anti-VEGF) therapy response.
Angiogenesis Inhibitors Metabolomics Macular Edema Vascular Endothelial Growth Factor A Chromatography, High Pressure Liquid Humans Lipidomics Diabetic Retinopathy Aqueous Humor Machine Learning Prospective Studies Biomarkers Female Aged Male Middle Aged Diabetes Mellitus, Type 2 Multiomics
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Prediction of Post-Treatment Visual Acuity in Age-Related Macular Degeneration Patients With an Interpretable Machine Learning Method.

Translational vision science & technology Sep 3, 2024
PURPOSE: We evaluated the features predicting visual acuity (VA) after one year in neovascular age-related macular degeneration (nAMD) patients.
Aged, 80 and over Male Middle Aged ROC Curve Angiogenesis Inhibitors Visual Acuity Tomography, Optical Coherence Indocyanine Green Intravitreal Injections Fluorescein Angiography Ranibizumab Humans Wet Macular Degeneration Machine Learning Retrospective Studies Female Aged
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