AIMC Topic: Antineoplastic Agents

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Anticancer activity of biologically synthesized silver and gold nanoparticles on mouse myoblast cancer cells and their toxicity against embryonic zebrafish.

Materials science & engineering. C, Materials for biological applications Dec 23, 2016
The aim of this study was to evaluate the anticancer activity of bioinspired silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) against mouse myoblast cancer cells (CC). Both AgNPs and AuNPs were biologically synthesized using Spinacia olera...
Embryo, Nonmammalian Acridine Orange Cell Shape Ethidium Photoacoustic Techniques Spinacia oleracea Zebrafish Caspases Myoblasts Toxicity Tests X-Ray Diffraction Plant Leaves Gold Metal Nanoparticles Silver Animals Mice Antineoplastic Agents Staining and Labeling Cell Line, Tumor Plant Extracts Apoptosis Cell Survival
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Enhanced photostability, radical scavenging and antitumor activity of indole-3-carbinol-loaded rose hip oil nanocapsules.

Materials science & engineering. C, Materials for biological applications Dec 14, 2016
This study aimed to develop poly(ε-caprolactone) nanocapsules loaded with indole-3-cabinol (I3C) using rose hip oil (RHO) or medium chain triglycerides (MCT) as oil core. In vitro radical scavenging activity (DPPH method), hemolysis, and antitumor ef...
Nanocapsules Free Radical Scavengers Photolysis MCF-7 Cells Humans Ultraviolet Rays Rosa Antineoplastic Agents Indoles Oils, Volatile Materials Testing Cell Line, Tumor Solubility Cell Survival
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Graphene oxide as a nanocarrier for controlled release and targeted delivery of an anticancer active agent, chlorogenic acid.

Materials science & engineering. C, Materials for biological applications Dec 5, 2016
We have synthesized graphene oxide using improved Hummer's method in order to explore the potential use of the resulting graphene oxide as a nanocarrier for an active anticancer agent, chlorogenic acid (CA). The synthesized graphene oxide and chlorog...
Humans Delayed-Action Preparations Hydrogen Bonding A549 Cells Microscopy, Electron, Transmission Oxides Antineoplastic Agents Thermogravimetry HeLa Cells Spectrum Analysis, Raman Hydrogen-Ion Concentration Graphite Spectroscopy, Fourier Transform Infrared Nanocomposites Chlorogenic Acid Hep G2 Cells Drug Liberation X-Ray Diffraction Cell Survival
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Efficacy according to blind independent central review: Post-hoc analyses from the phase III, randomized, multicenter, IPASS study of first-line gefitinib versus carboplatin/paclitaxel in Asian patients with EGFR mutation-positive advanced NSCLC.

Lung cancer (Amsterdam, Netherlands) Nov 30, 2016
OBJECTIVE: The Phase III, randomized, open-label IPASS study (NCT00322452) of first-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) gefitinib versus carboplatin/paclitaxel for Asian patients with advanced non-small-cell lun...
Female Aged Aged, 80 and over Gefitinib Male Quinazolines Middle Aged Paclitaxel Antineoplastic Agents Disease-Free Survival Lung Neoplasms Smoking Humans Antineoplastic Combined Chemotherapy Protocols ErbB Receptors Adenocarcinoma Protein Kinase Inhibitors Randomized Controlled Trials as Topic Carcinoma, Non-Small-Cell Lung Neoplasm Staging Mutation Asian People Carboplatin
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Vitamin E (α-Tocopherol) Exhibits Antitumour Activity on Oral Squamous Carcinoma Cells ORL-48.

Integrative cancer therapies Nov 10, 2016
Cancers involving the oral cavity, head, and neck regions are often treated with cisplatin. In cancer therapy, the main target is to eliminate unwanted cancerous cells. However, reports on the nonselective nature of this drug have raised few concerns...
Cell Cycle Checkpoints Humans Vitamin E Carcinoma, Squamous Cell Oxidative Stress Annexin A5 Antineoplastic Agents G1 Phase Antioxidants Cell Line, Tumor Apoptosis Resting Phase, Cell Cycle Cisplatin alpha-Tocopherol
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Prediction of anti-cancer drug response by kernelized multi-task learning.

Artificial intelligence in medicine Oct 3, 2016
MOTIVATION: Chemotherapy or targeted therapy are two of the main treatment options for many types of cancer. Due to the heterogeneous nature of cancer, the success of the therapeutic agents differs among patients. In this sense, determination of chem...
Computer Simulation Neoplasms Antineoplastic Agents Cell Line, Tumor Drug Resistance, Neoplasm Humans Machine Learning Algorithms Forecasting Databases, Factual
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Risk Assessment for Venous Thromboembolism in Chemotherapy-Treated Ambulatory Cancer Patients.

Medical decision making : an international journal of the Society for Medical Decision Making Aug 19, 2016
OBJECTIVE: To design a precision medicine approach aimed at exploiting significant patterns in data, in order to produce venous thromboembolism (VTE) risk predictors for cancer outpatients that might be of advantage over the currently recommended mod...
Lipids Anticoagulants Neoplasm Staging Venous Thromboembolism Outpatients Risk Assessment Neoplasms Antineoplastic Agents Body Mass Index Health Status Humans Machine Learning Risk Factors
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Automated identification of molecular effects of drugs (AIMED).

Journal of the American Medical Informatics Association : JAMIA Apr 23, 2016
INTRODUCTION: Genomic profiling information is frequently available to oncologists, enabling targeted cancer therapy. Because clinically relevant information is rapidly emerging in the literature and elsewhere, there is a need for informatics technol...
Antineoplastic Agents Natural Language Processing Information Storage and Retrieval Semantics Humans MEDLINE Precision Medicine Clinical Trials as Topic Neoplasms Unified Medical Language System
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Investigation of the mutagenic and genotoxic activities of LLL-3, a STAT3 inhibitor.

Drug and chemical toxicology Apr 10, 2016
LLL-3, an anthracene derived compound, has been shown to be a promising therapeutic agent for the treatment of some kinds of cancer such as chronic myeloid leukemia and glioblastoma. However, no data regarding the toxic properties of this compound ha...
Micronucleus Tests Mutagenicity Tests Cell Culture Techniques Micronuclei, Chromosome-Defective Dose-Response Relationship, Drug Cell Line Salmonella typhimurium STAT3 Transcription Factor Anthraquinones Macrophages Animals Antineoplastic Agents Mice
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SNRFCB: sub-network based random forest classifier for predicting chemotherapy benefit on survival for cancer treatment.

Molecular bioSystems Feb 11, 2016
Adjuvant chemotherapy (CTX) should be individualized to provide potential survival benefit and avoid potential harm to cancer patients. Our goal was to establish a computational approach for making personalized estimates of the survival benefit from ...
Humans Breast Neoplasms Male Neoplasms Antineoplastic Agents Lung Neoplasms Neural Networks, Computer Machine Learning Prognosis Female Reproducibility of Results Kaplan-Meier Estimate Chemotherapy, Adjuvant Computational Biology Treatment Outcome Support Vector Machine Models, Statistical Area Under Curve
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