AIMC Topic: Apoptosis
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Preparation, Characterization, and Antitumor Activities of Miriplatin-Loaded Liposomes.
Journal of pharmaceutical sciences
Dec 22, 2015
Because of the insolubility of miriplatin in water, miriplatin and lipiodol suspension is the sole formulation of miriplatin approved in Japan to treat hepatocellular carcinoma by transcatheter arterial chemoembolization. Until now, there have been n...
O-naphthoquinone isolated from Capraria biflora L. induces selective cytotoxicity in tumor cell lines.
Genetics and molecular research : GMR
Dec 21, 2015
Biflorin is an o-naphthoquinone isolated from the roots of the plant Capraria biflora L. (Scrophulariaceae). In this study, the cytotoxic effects of biflorin were verified, and late apoptosis was detected in various cancer cell lines by in situ analy...
Modified citrus pectin stops progression of liver fibrosis by inhibiting galectin-3 and inducing apoptosis of stellate cells.
Canadian journal of physiology and pharmacology
Dec 16, 2015
Modified citrus pectin (MCP) is a pH modified form of the dietary soluble citrus peel fiber known as pectin. The current study aims at testing its effect on liver fibrosis progression. Rats were injected with CCl4 (1 mL/kg, 40% v/v, i.p., twice a wee...
Citrus
Carbon Tetrachloride
Pectins
Liver Cirrhosis, Experimental
Disease Progression
Dietary Fiber
Biomarkers
Dietary Supplements
Oxidative Stress
Animals
Lipid Peroxidation
Liver
Antioxidants
Male
Fruit
Galectin 3
Rats, Sprague-Dawley
Hepatic Stellate Cells
Solubility
Apoptosis
Hydrogen-Ion Concentration
Hot Temperature
Neuroprotective effects of the Phellinus linteus ethyl acetate extract against H2O2-induced apoptotic cell death of SK-N-MC cells.
Nutrition research (New York, N.Y.)
Nov 11, 2015
Numerous studies have suggested that neuronal cells are protected against oxidative stress-induced cell damage by antioxidants, such as polyphenolic compounds. Phellinus linteus (PL) has traditionally been used to treat various symptoms in East Asian...
Medicine, Korean Traditional
Phellinus
Fruiting Bodies, Fungal
Gene Expression Regulation, Enzymologic
Oxidoreductases
Ethnopharmacology
Apoptosis
Biological Products
Polyphenols
Nerve Tissue Proteins
Acetates
Polysaccharides
Neurons
Solvents
MAP Kinase Signaling System
Basidiomycota
Cell Line, Tumor
Oxidative Stress
Antioxidants
Plant Extracts
Neuroprotective Agents
Humans
Brain
Republic of Korea
Follicle-stimulating hormone-induced rescue of cumulus cell apoptosis and enhanced development ability of buffalo oocytes.
Domestic animal endocrinology
Oct 31, 2015
The effect of follicle-stimulating hormone (FSH) on apoptotic status of cumulus cells, expression of proapoptotic and antiapoptotic genes, and development rate of in vitro fertilization-produced buffalo embryos were investigated. FSH supplementation ...
Cytotoxic response of platinum-coated gold nanorods in human breast cancer cells at very low exposure levels.
Environmental toxicology
Apr 6, 2015
Because of unique optical behavior gold nanorods (GNRs) have attracted attention for the application in biomedical field such as bio-sensing, bio-imaging and hyperthermia. However, toxicological response of GNRs is controversial due to their differen...
G1 Phase Cell Cycle Checkpoints
MCF-7 Cells
RNA, Messenger
Down-Regulation
Up-Regulation
Gold
Apoptosis
Humans
Nanotubes
Membrane Potential, Mitochondrial
Reactive Oxygen Species
Female
Platinum
Acetylcysteine
Caspase 3
Breast Neoplasms
Proto-Oncogene Proteins c-bcl-2
Particle Size
Real-Time Polymerase Chain Reaction
Caspase 9
Cellular level robotic surgery: Nanodissection of intermediate filaments in live keratinocytes.
Nanomedicine : nanotechnology, biology, and medicine
Sep 6, 2014
We present the nanosurgery on the cytoskeleton of live cells using AFM based nanorobotics to achieve adhesiolysis and mimic the effect of pathophysiological modulation of intercellular adhesion. Nanosurgery successfully severs the intermediate filame...
Machine learning Reveals ATM and CNOT6L as critical factors in Cataract pathogenesis.
Experimental eye research
Aug 1, 2025
OBJECTIVE: Cataract, a common age-related blinding eye disease, has a complex pathogenesis. This study aims to identify key genes and potential mechanisms associated with cataracts, offering new targets and insights for its prevention and treatment.
Structure-based artificial intelligence-aided design of MYC-targeting degradation drugs for cancer therapy.
Biochemical and biophysical research communications
Jun 20, 2025
The MYC protein is an oncoprotein that plays a crucial role in various cancers. Although its significance has been well recognized in research, the development of drugs targeting MYC remains relatively slow. In this study, we developed a novel MYC pe...
Integrated machine learning survival framework develops a prognostic model based on macrophage-related genes and programmed cell death signatures in a multi-sample Kidney renal clear cell carcinoma.
Cell biology and toxicology
May 30, 2025
BACKGROUND: Macrophages are closely associated with the progression of Kidney renal clear cell carcinoma (KIRC) and can influence programmed cell death (PCD) of tumour cells. To identify prognostic biomarkers for KIRC, it is essential to investigate ...
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