AIMC Topic: Cadherins

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Identification and validation of epithelial‑mesenchymal transition‑related genes for diabetic nephropathy by WGCNA and machine learning.

Molecular medicine reports Jul 11, 2025
Diabetic nephropathy (DN) is the main cause of end‑stage renal disease, with epithelial‑mesenchymal transition (EMT) serving a key role in its initiation and progression. Nevertheless, the precise mechanisms involved remain unidentified. The present ...
Vimentin ROC Curve Protein Interaction Maps Gene Regulatory Networks Mice Diabetic Nephropathies Computational Biology Databases, Genetic Epithelial-Mesenchymal Transition Cadherins Fibronectins Humans Machine Learning Animals Male Gene Expression Profiling
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A machine-learning-based approach to predict early hallmarks of progressive hearing loss.

Hearing research Jun 6, 2025
Machine learning (ML) techniques are increasingly being used to improve disease diagnosis and treatment. However, the application of these computational approaches to the early diagnosis of age-related hearing loss (ARHL), the most common sensory def...
Animals Male Disease Progression Mice Age Factors Early Diagnosis Humans Hearing Machine Learning Auditory Threshold Phenotype Evoked Potentials, Auditory, Brain Stem Female Disease Models, Animal Presbycusis Mice, Inbred C57BL Predictive Value of Tests Signal Processing, Computer-Assisted Cadherins
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Salivary and serum levels of soluble E-cadherin in patients with gastrointestinal cancers: A comparative study.

Journal of cancer research and therapeutics Apr 27, 2023
AIM: According to the literature, high levels of salivary soluble E-cadherin may be lined to advanced stage and poor prognosis in cancers. This research aimed at comparing salivary and serum levels of soluble E-cadherin in cases with esophageal, gast...
Enzyme-Linked Immunosorbent Assay Humans Cadherins Stomach Neoplasms Gastrointestinal Neoplasms Colorectal Neoplasms Case-Control Studies
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Machine learning reveals mesenchymal breast carcinoma cell adaptation in response to matrix stiffness.

PLoS computational biology Jul 23, 2021
Epithelial-mesenchymal transition (EMT) and its reverse process, mesenchymal-epithelial transition (MET), are believed to play key roles in facilitating the metastatic cascade. Metastatic lesions often exhibit a similar epithelial-like state to that ...
Machine Learning Female Tumor Microenvironment Biomarkers, Tumor Cell Line, Tumor Humans Epithelial-Mesenchymal Transition Cadherins Models, Biological Vimentin Neoplasm Metastasis Computational Biology Triple Negative Breast Neoplasms Cell Proliferation Antigens, CD Cell Count Extracellular Matrix Biophysical Phenomena Cell Adhesion Cell Shape Adaptation, Physiological
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Topaz-Denoise: general deep denoising models for cryoEM and cryoET.

Nature communications Oct 15, 2020
Cryo-electron microscopy (cryoEM) is becoming the preferred method for resolving protein structures. Low signal-to-noise ratio (SNR) in cryoEM images reduces the confidence and throughput of structure determination during several steps of data proces...
Data Collection Signal-To-Noise Ratio Cryoelectron Microscopy Resin Cements Machine Learning Particle Size Cadherins
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Quantifying drug tissue biodistribution by integrating high content screening with deep-learning analysis.

Scientific reports Sep 1, 2020
Quantitatively determining in vivo achievable drug concentrations in targeted organs of animal models and subsequent target engagement confirmation is a challenge to drug discovery and translation due to lack of bioassay technologies that can discrim...
Fluorescent Dyes Cadherins High-Throughput Screening Assays Intestine, Small Carbocyanines Tissue Distribution Immunoconjugates Colon Drug Discovery Deep Learning Image Processing, Computer-Assisted Mice Animals
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Analysis of gene expression profiles of lung cancer subtypes with machine learning algorithms.

Biochimica et biophysica acta. Molecular basis of disease Apr 28, 2020
Lung cancer is one of the most common cancer types worldwide and causes more than one million deaths annually. Lung adenocarcinoma (AC) and lung squamous cell cancer (SCC) are two major lung cancer subtypes and have different characteristics in sever...
Serpins Adenocarcinoma of Lung Cystatin A Gene Expression Regulation, Neoplastic Carcinoma, Squamous Cell Gene Expression Profiling Transcriptome Lung Neoplasms Computational Biology Transcription Factors Diagnosis, Differential Cadherins Datasets as Topic Humans Machine Learning Tumor Suppressor Proteins Adenosine Triphosphatases Terminology as Topic Membrane Transport Proteins Monte Carlo Method
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Carboxybetaine-modified succinylated chitosan-based beads encourage pancreatic β-cells (Min-6) to form islet-like spheroids under in vitro conditions.

Journal of materials science. Materials in medicine Dec 30, 2017
In vitro, pancreatic β-cells tend to reduce their ability to aggregate into islets and lose insulin-producing ability, likely due to insufficient cell-cell and cell-matrix interactions that are essential for β-cell retention, viability and functional...
Homeodomain Proteins Mice Spectroscopy, Fourier Transform Infrared Scattering, Radiation Animals Carbon Cell Survival Spheroids, Cellular Insulin Microscopy, Electron, Scanning Chitosan Trans-Activators Surface Properties Microscopy, Fluorescence Insulin-Secreting Cells Cadherins Cell Culture Techniques Molecular Dynamics Simulation Betaine Insulin Secretion Lasers
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The Interplay Between Epithelial-Mesenchymal Transition (EMT) and the Thyroid Hormones-αvβ3 Axis in Ovarian Cancer.

Hormones & cancer Dec 19, 2017
Ovarian cancer is a highly metastatic disease. The metastatic potential is enhanced by epithelial to mesenchymal transition (EMT) in which αvβ3 integrin plays a role. Thyroid hormones (L-thyroxine, T4, and 3,5,3'-triiodo-L-thyronine, T3) bind this in...
Zinc Finger E-box-Binding Homeobox 1 Vimentin Triiodothyronine beta Catenin Integrin alphaVbeta3 Snail Family Transcription Factors Humans Zonula Occludens-1 Protein Epithelial-Mesenchymal Transition Thyroxine Cadherins Thyroid Hormones Female Cell Line, Tumor Gene Expression Regulation, Neoplastic Signal Transduction Ovarian Neoplasms
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The protective effects of bone morphogenetic protein-7 against epithelial injury and matrix metalloproteases upregulation induced by silica in vitro.

Human & experimental toxicology Oct 20, 2016
OBJECTIVE: We investigate the effects of bone morphogenetic protein-7 (BMP-7) on models with silica-induced and macrophage-mediated fibrosis and its possible mechanisms in vitro.
Epithelial Cells Cadherins Fibronectins Vimentin Matrix Metalloproteinases Pulmonary Surfactant-Associated Protein C Quartz Smad Proteins Animals Up-Regulation Mice Collagen Type I Rats Collagen Type III Cell Line Bone Morphogenetic Protein 7 Hydroxyproline
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