AIMC Topic: Cytokines

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Anticancer and anti-inflammatory activities of girinimbine isolated from .

Drug design, development and therapy Dec 28, 2016
Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a...
Cell Survival Antineoplastic Agents, Phytogenic Drug Screening Assays, Antitumor Nitric Oxide Structure-Activity Relationship Zebrafish Humans Anti-Inflammatory Agents, Non-Steroidal Cell Proliferation Alkaloids Cytokines Apoptosis HT29 Cells Animals Lipopolysaccharides Tumor Cells, Cultured Mice Dose-Response Relationship, Drug Murraya
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TNF-α increases in the CSF of children with acute lymphoblastic leukemia before CNS relapse.

Blood cells, molecules & diseases Dec 23, 2016
There is scarce information regarding the concentration of cytokines in cerebrospinal fluid (CSF) of children with acute lymphoblastic leukemia (ALL) and their clinical association with CNS status. A prospective analysis of 40 patients <18years with ...
Chemokine CCL2 Precursor Cell Lymphoblastic Leukemia-Lymphoma Recurrence Central Nervous System Neoplasms Time Factors Child, Preschool Child ROC Curve Predictive Value of Tests Humans Tumor Necrosis Factor-alpha Cytokines Female Interleukin-6 Male Prospective Studies Infant Adolescent
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Cytokine Changes following Acute Ethanol Intoxication in Healthy Men: A Crossover Study.

Mediators of inflammation Dec 20, 2016
Alcohol is a known modulator of the innate immune system. Owing to the absence of human studies, alcohol's effect on circulating cytokine profile remains unclear. We investigated the effect of acute high dose alcohol consumption on systemic cytokine ...
Middle Aged Fasting Cohort Studies Time Factors Ethanol Humans Cytokines Young Adult Adult Male Double-Blind Method Cross-Over Studies Healthy Volunteers Alcoholic Beverages Alcoholic Intoxication
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Robot-assisted mechanical therapy attenuates stroke-induced limb skeletal muscle injury.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology Nov 28, 2016
The efficacy and optimization of poststroke physical therapy paradigms is challenged in part by a lack of objective tools available to researchers for systematic preclinical testing. This work represents a maiden effort to develop a robot-assisted me...
Stroke Rehabilitation Robotics Myostatin Regional Blood Flow Hindlimb Physical Therapy Modalities Cytokines Animals Male Rats, Wistar Rats Brain-Derived Neurotrophic Factor Muscle, Skeletal
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Comparison of inflammatory responses following robotic and open colorectal surgery: a prospective study.

International journal of colorectal disease Nov 4, 2016
PURPOSE: Robotic colorectal surgery continues to rise in popularity, but there remains little evidence on the stress response following the procedure. The aim of this study was to evaluate the inflammatory response to robotic colorectal surgery and c...
Humans Cytokines Prospective Studies Female Robotics Calcitonin Demography Perioperative Care Colorectal Surgery Aged Male Inflammation Treatment Outcome C-Reactive Protein
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Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults.

Clinical nutrition (Edinburgh, Scotland) Dec 24, 2015
BACKGROUND & AIMS: Mortality resulting from influenza (flu) virus infections occurs primarily in the elderly through declining immunity. Studies in mice have suggested beneficial effects of selenium (Se) supplementation on immunity to flu but similar...
T-Lymphocytes Male Middle Aged Diet Selenium Humans Cytokines Female Dietary Supplements Double-Blind Method Saliva Influenza, Human Influenza Vaccines Immunity, Cellular Antibodies, Viral Cell Proliferation Body Mass Index Dose-Response Relationship, Drug Immunoglobulins Immunoglobulin A
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Beneficial effects of Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic syndrome: A randomized trial. Effects of probiotics on metabolic syndrome.

Nutrition (Burbank, Los Angeles County, Calif.) Dec 7, 2015
OBJECTIVE: Human studies have shown the beneficial effects of probiotic microorganisms on the parameters of metabolic syndrome (MetS) and other cardiovascular risks, but to our knowledge the effect of Bifidobacterium lactis has not yet been reported....
Probiotics Bifidobacterium Humans Cytokines Female Young Adult Adult Male Middle Aged Adolescent Metabolic Syndrome Lipids
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Muscle damage and immune responses to prolonged exercise in environmental extreme conditions.

The Journal of sports medicine and physical fitness Sep 1, 2015
BACKGROUND: This study aimed to investigate the effect of prolonged exercise with and without a thermal clamp on leukocyte cell, stress hormones, cytokine and muscle damage responses.
Humans Cytokines Biomarkers Young Adult Adult Male Random Allocation Exercise Hot Temperature Exercise Test Humidity Healthy Volunteers Leukocyte Count Physical Endurance Muscle Fatigue Stress, Physiological
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Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways.

Environmental toxicology May 26, 2015
Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially ...
Humans NF-kappa B Tumor Necrosis Factor-alpha Cell Movement Benzhydryl Compounds Cells, Cultured Lipopolysaccharides Cell Migration Assays, Macrophage Female Macrophages Phenols Chemotaxis, Leukocyte Cytokines Interleukin-1beta Middle Aged Diethylhexyl Phthalate Estradiol Inflammation Signal Transduction
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Machine learning methods enable predictive modeling of antibody feature:function relationships in RV144 vaccinees.

PLoS computational biology Apr 13, 2015
The adaptive immune response to vaccination or infection can lead to the production of specific antibodies to neutralize the pathogen or recruit innate immune effector cells for help. The non-neutralizing role of antibodies in stimulating effector ce...
Antibody-Dependent Cell Cytotoxicity HIV Antibodies HIV Antigens HIV Infections Computational Biology Humans HIV-1 Machine Learning Models, Immunological Cytokines AIDS Vaccines
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