AIMC Topic: Disease Models, Animal

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Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.

Proceedings of the National Academy of Sciences of the United States of America Jan 19, 2021
Exon splicing triggered by unpredicted genetic mutation can cause translational variations in neurodegenerative disorders. In this study, we discover Alzheimer's disease (AD)-specific single-nucleotide variants (SNVs) and abnormal exon splicing of ph...
Humans Computer Simulation Animals Deep Learning Disease Models, Animal Alzheimer Disease High-Throughput Screening Assays Genome, Human RNA Splicing Exons Genome-Wide Association Study Mice Genetic Predisposition to Disease Polymorphism, Single Nucleotide RNA, Messenger Phospholipase C gamma
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The Human Phenotype Ontology in 2021.

Nucleic acids research Jan 8, 2021
The Human Phenotype Ontology (HPO, https://hpo.jax.org) was launched in 2008 to provide a comprehensive logical standard to describe and computationally analyze phenotypic abnormalities found in human disease. The HPO is now a worldwide standard for ...
Genome Biological Ontologies Neonatal Screening Terminology as Topic Disease International Cooperation Humans Computational Biology Software Disease Models, Animal Animals Phenotype Internet Pharmacogenetics Databases, Factual Genotype Infant, Newborn
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Mouse Genome Database (MGD): Knowledgebase for mouse-human comparative biology.

Nucleic acids research Jan 8, 2021
The Mouse Genome Database (MGD; http://www.informatics.jax.org) is the community model organism knowledgebase for the laboratory mouse, a widely used animal model for comparative studies of the genetic and genomic basis for human health and disease. ...
Humans COVID-19 SARS-CoV-2 Animals Knowledge Bases Information Storage and Retrieval Epidemics Gene Ontology Data Curation Genome Mice Genomics Databases, Genetic Disease Models, Animal Internet
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Machine Learning-Supported Analyses Improve Quantitative Histological Assessments of Amyloid-β Deposits and Activated Microglia.

Journal of Alzheimer's disease : JAD Jan 1, 2021
BACKGROUND: Detailed pathology analysis and morphological quantification is tedious and prone to errors. Automatic image analysis can help to increase objectivity and reduce time. Here, we present the evaluation of the DeePathology STUDIO™ for automa...
Disease Models, Animal Microglia Machine Learning Alzheimer Disease Animals Mice, Transgenic Image Processing, Computer-Assisted Plaque, Amyloid Mice
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Anti-inflammatory and antibacterial activities of P. petiolosa (Christ) Ching ethyl acetate extract against S. aureus in mice.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
P. petiolosa as a typical Chinese herbal medicine has been generally utilized as Chinese native medicine formulation for treatment of chronic bronchitis, bronchial asthma and pneumoconiosis. The objective of this study was to evaluate the anti-inflam...
Anti-Inflammatory Agents Anti-Bacterial Agents Inflammation Mediators Membrane Proteins Tumor Necrosis Factor-alpha Acetates Nitric Oxide Synthase Type II Staphylococcus aureus Animals Solvents Pneumonia, Staphylococcal Disease Models, Animal Lung Bacterial Load Polypodiaceae Mice, Inbred BALB C Plant Extracts Heme Oxygenase-1 Plant Leaves
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Mantis-ml: Disease-Agnostic Gene Prioritization from High-Throughput Genomic Screens by Stochastic Semi-supervised Learning.

American journal of human genetics May 7, 2020
Access to large-scale genomics datasets has increased the utility of hypothesis-free genome-wide analyses. However, gene signals are often insufficiently powered to reach experiment-wide significance, triggering a process of laborious triaging of gen...
Exome Area Under Curve Epilepsy Amyotrophic Lateral Sclerosis Supervised Machine Learning Stochastic Processes Humans Neural Networks, Computer Reproducibility of Results Animals Deep Learning Genetic Association Studies Renal Insufficiency, Chronic Disease Models, Animal ROC Curve Mice Genomics
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Neuroprotective effects of Suhexiang Wan on the in vitro and in vivo models of Parkinson's disease.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Dec 1, 2019
OBJECTIVE: To examine the role of KSOP1009 (a modified formulation of Suhexiang Wan essential oil) in an animal model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection.
Neuroprotective Agents Disease Models, Animal Reactive Oxygen Species Cell Survival Parkinson Disease Brain Animals Substantia Nigra Drugs, Chinese Herbal Humans Male Blotting, Western Mice, Inbred ICR Cell Line, Tumor Mitochondria Mice Immunohistochemistry
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Machine Learning Approach for Predicting Past Environmental Exposures From Molecular Profiling of Post-Exposure Human Serum Samples.

Journal of occupational and environmental medicine Dec 1, 2019
OBJECTIVE: To develop an approach for a retrospective analysis of post-exposure serum samples using diverse molecular profiles.
Cotinine Environmental Exposure Sex Factors Smoking Tobacco Smoke Pollution Adolescent Support Vector Machine Age Factors Disease Models, Animal Humans Mice, Inbred C57BL Adult Machine Learning Biomarkers Animals Female Male Young Adult
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Effects of extracts from Chuanwu (Aconitum Carmichaelii) and Banxia (Rhizoma Pinelliae) on excisional wound healing in a rat's model.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Feb 1, 2019
OBJEVTIVE: To investigate the effects of extracts from Chuanwu (Aconitum Carmichaelii) and Banxia (Rhizoma Pinelliae) on the excisional wound healing in a rat's model.
Drugs, Chinese Herbal Transforming Growth Factor beta1 Aconitum Fibroblast Growth Factor 2 Pinellia Rats Interleukin-10 Interleukin-2 Rats, Sprague-Dawley Tumor Necrosis Factor-alpha Wound Healing Interleukin-4 Disease Models, Animal Animals Real-Time Polymerase Chain Reaction
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Network Tomography for Understanding Phenotypic Presentations in Aortic Stenosis.

JACC. Cardiovascular imaging Feb 1, 2019
OBJECTIVES: This study sought to build a patient-patient similarity network using multiple features of left ventricular (LV) structure and function in patients with aortic stenosis (AS). The study further validated the observations in an experimental...
Humans Machine Learning Female Reproducibility of Results Aged Male Ventricular Function, Left Echocardiography Aged, 80 and over Cross-Sectional Studies Animals Image Interpretation, Computer-Assisted Aortic Valve Stenosis Heart Valve Prosthesis Implantation Aortic Valve Middle Aged Balloon Valvuloplasty Predictive Value of Tests Disease Progression Mice, Knockout Severity of Illness Index Heart Ventricles Time Factors Disease Models, Animal
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