AIMC Topic: Down-Regulation

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Discovery of urinary biosignatures for tuberculosis and nontuberculous mycobacteria classification using metabolomics and machine learning.

Scientific reports Jul 3, 2024
Nontuberculous mycobacteria (NTM) infection diagnosis remains a challenge due to its overlapping clinical symptoms with tuberculosis (TB), leading to inappropriate treatment. Herein, we employed noninvasive metabolic phenotyping coupled with comprehe...
Biomarkers Aged Male Middle Aged ROC Curve Metabolomics Humans Machine Learning Phenotype Amino Acids Random Forest Tuberculosis Mycobacterium Infections, Nontuberculous Down-Regulation Up-Regulation Models, Statistical Liquid Chromatography-Mass Spectrometry Metabolome Diagnosis, Differential Area Under Curve
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Different spexin level in obese vs normal weight children and its relationship with obesity related risk factors.

Nutrition, metabolism, and cardiovascular diseases : NMCD Nov 23, 2019
BACKGROUND AND AIMS: Spexin (SPX) is a novel peptide recently discovered as an important regulatory adipokine in obesity and related metabolic diseases. The aim of the current study was to determine the potential role of Circulating levels of SPX in ...
Age Factors Case-Control Studies Adiposity Adolescent Down-Regulation Humans Peptide Hormones Biomarkers Child Weight Gain Female Insulin Resistance Risk Factors Pediatric Obesity Male
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Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line.

Analytical cellular pathology (Amsterdam) Aug 4, 2019
Human hepatocellular carcinoma (HCC) is the most common and recurrent type of primary adult liver cancer without any effective therapy. Plant-derived compounds acting as anticancer agents can induce apoptosis by targeting several signaling pathways. ...
Up-Regulation Gene Ontology Humans Carcinoma, Hepatocellular Liver Neoplasms RNA, Messenger Gene Expression Regulation, Neoplastic Hep G2 Cells Lactones Down-Regulation
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Decreased circulating catestatin levels are associated with coronary artery disease: The emerging anti-inflammatory role.

Atherosclerosis Dec 24, 2018
BACKGROUND AND AIMS: The neuropeptide catestatin (CST) is an endogenous nicotinic cholinergic antagonist that acts as pleiotropic cardiac protective hormone. This study investigated the association between CST and coronary artery disease (CAD) and th...
Peptide Fragments Anti-Inflammatory Agents Coronary Artery Disease Atherosclerosis Down-Regulation Male Severity of Illness Index Case-Control Studies Humans Disease Models, Animal Plaque, Atherosclerotic Cells, Cultured Human Umbilical Vein Endothelial Cells Cytokines Biomarkers Cell Adhesion Molecules Female Angiotensin-Converting Enzyme 2 Animals Chromogranin A Mice, Knockout, ApoE Peptidyl-Dipeptidase A
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Gas chromatography-mass spectrometry metabolomic study of lipopolysaccharides toxicity on rat basophilic leukemia cells.

Chemico-biological interactions Dec 22, 2017
Lipopolysaccharide (LPS) can lead to uncontrollable cytokine production, fatal sepsis syndrome and depression/multiple organ failure, as pathophysiologic demonstration. Various toxic effects of LPS have been extensively reported, mainly on the toxici...
Animals Cell Line, Tumor Rats Apoptosis Lipopolysaccharides Amino Acids Metabolomics Gas Chromatography-Mass Spectrometry Mast Cells Down-Regulation Principal Component Analysis Leukemia, Basophilic, Acute Metabolic Networks and Pathways Discriminant Analysis
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Effect of abiotic and biotic stress factors analysis using machine learning methods in zebrafish.

Comparative biochemistry and physiology. Part D, Genomics & proteomics Nov 11, 2017
In order to understand the mechanisms underlying stress responses, meta-analysis of transcriptome is made to identify differentially expressed genes (DEGs) and their biological, molecular and cellular mechanisms in response to stressors. The present ...
Animals Gene Expression Profiling Fish Proteins Gene Ontology Oligonucleotide Array Sequence Analysis Supervised Machine Learning Zebrafish Down-Regulation Stress, Physiological Up-Regulation Transcription Factors Support Vector Machine MicroRNAs Principal Component Analysis Meta-Analysis as Topic
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Changes in maternal placental growth factor levels during term labour.

Placenta Nov 8, 2017
UNLABELLED: Placental growth factor (PlGF) has important angiogenic function that is critical to placental development. Lower levels of PlGF are associated with fetal growth restriction, pre-eclampsia and intrapartum fetal compromise. The aim of this...
Placenta Growth Factor Term Birth Biomarkers Reproducibility of Results Humans Pregnancy Prospective Studies Adult Female Cohort Studies Cesarean Section Elective Surgical Procedures Parity Down-Regulation Labor, Obstetric
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Investigating the antifungal activity and mechanism of a microbial pesticide Shenqinmycin against Phoma sp.

Pesticide biochemistry and physiology Aug 30, 2017
Tea white scab (TWS) is a major disease affecting tea trees in mid-elevation regions and often occurs during rainy seasons with low temperatures. This disease is caused by the fungal pathogen Phoma sp. TWS can infect young stems, tender leaves, and t...
Mycelium Plant Structures Plant Diseases Microbial Sensitivity Tests Oxidation-Reduction Ascomycota RNA, Messenger Antifungal Agents Fungal Proteins Culture Media Tandem Mass Spectrometry Gene Expression Regulation, Fungal Down-Regulation Chromatography, Liquid Nanotechnology Genes, Fungal Up-Regulation Camellia sinensis Energy Metabolism Phenazines Homeostasis
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Histone deacetylase 2 is decreased in peripheral blood pro-inflammatory CD8+ T and NKT-like lymphocytes following lung transplant.

Respirology (Carlton, Vic.) Nov 6, 2016
BACKGROUND AND OBJECTIVE: Immunosuppression therapy following lung transplantation fails to prevent chronic rejection in many patients, which is associated with lack of suppression of cytotoxic mediators and pro-inflammatory cytokines in peripheral b...
Lung Transplantation Down-Regulation Interferon-gamma Granzymes Histone Deacetylase 2 Perforin Adult Male Middle Aged Graft Survival CD8-Positive T-Lymphocytes Humans Tumor Necrosis Factor-alpha Female
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Downregulation of serum DKK-1 predicts poor prognosis in patients with papillary thyroid cancer.

Genetics and molecular research : GMR Dec 29, 2015
The Wnt inhibitor dickkopf-1 (DKK-1) has been shown to be closely correlated with tumor initiation and progression in various types of cancers. However, the serum level of DKK-1 in patients with papillary thyroid cancer (PTC) and its potential clinic...
Adolescent Thyroid Gland Thyroid Neoplasms Enzyme-Linked Immunosorbent Assay Lymphatic Metastasis Gene Expression Adult Biomarkers, Tumor Male Middle Aged Case-Control Studies Intercellular Signaling Peptides and Proteins Down-Regulation Carcinoma, Papillary Thyroid Cancer, Papillary Neoplasm Staging Carcinoma Neoplasm Recurrence, Local Survival Analysis Tumor Burden Humans Prognosis Female Risk Factors Aged
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