AIMC Topic: Matrix Metalloproteinase 9

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Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro.

The Kaohsiung journal of medical sciences Dec 30, 2016
Achyranthes bidentate Blume (Niuxi) is often employed for treatment of arthritis in Traditional Chinese Medicine and possesses anti-inflammatory properties. Phytochemical and pharmacological studies proved the oleanane-type saponins to be the main bi...
bcl-Associated Death Protein bcl-X Protein Inflammation Signal Transduction Rats, Sprague-Dawley Anti-Inflammatory Agents, Non-Steroidal Plant Roots Apoptosis Caspase 3 Animals Male Plant Extracts Rats Gene Expression Regulation Proliferating Cell Nuclear Antigen Cyclooxygenase 2 Primary Cell Culture Achyranthes bcl-2-Associated X Protein Cartilage, Articular Interleukin-1beta Chondrocytes Matrix Metalloproteinase 3 NF-kappa B Matrix Metalloproteinase 9 Saponins Tumor Suppressor Protein p53
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Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells.

Oxidative medicine and cellular longevity Dec 28, 2015
Hericium erinaceus (HE) is an edible mushroom that has been shown to exhibit anticancer and anti-inflammatory activities. We investigated the antiangiogenic and antioxidant potentials of ethanol extracts of HE in human endothelial (EA.hy926) cells up...
Angiogenesis Inducing Agents Basidiomycota NF-kappa B Endothelial Cells Anti-Inflammatory Agents Heme Oxygenase-1 Inflammation Intercellular Adhesion Molecule-1 Matrix Metalloproteinase 9 NF-E2-Related Factor 2 Glutathione Signal Transduction Neovascularization, Pathologic Angiogenesis Inhibitors Reactive Oxygen Species Humans Tumor Necrosis Factor-alpha Antioxidants
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Molecular mechanisms of suberoylanilide hydroxamic acid in the inhibition of TGF-β1-mediated canine corneal fibrosis.

Veterinary ophthalmology Nov 12, 2015
OBJECTIVE: To investigate molecular mechanisms mediating anti-fibrotic effect of SAHA in the canine cornea using an in vitro model. We hypothesized that SAHA attenuates corneal fibrosis by modulating Smad-dependent and, to a lesser extent, Smad-indep...
p38 Mitogen-Activated Protein Kinases Matrix Metalloproteinase 9 Dogs Hydroxamic Acids Vorinostat Fibrosis Histone Deacetylase Inhibitors Cornea Animals Transforming Growth Factor beta1 Cells, Cultured
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Danhong huayu koufuye prevents deep vein thrombosis through anti-inflammation in rats.

The Journal of surgical research Nov 11, 2015
BACKGROUND: Danhong huayu koufuye (DHK) has traditionally been used clinically for a long time in China. This study was to evaluate the effect of DHK in treating deep vein thrombosis (DVT) in rats and explore its possible mechanism.
Male Venous Thrombosis Rats, Sprague-Dawley Blood Coagulation Tumor Necrosis Factor-alpha Interleukin-6 Animals Blood Cell Count Random Allocation Vena Cava, Inferior Thromboplastin Drugs, Chinese Herbal Matrix Metalloproteinase 9 Drug Evaluation, Preclinical
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Integrating bioinformatics and machine learning to unravel shared mechanisms and biomarkers in chronic obstructive pulmonary disease and type 2 diabetes.

Postgraduate medical journal May 18, 2025
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM) are on the rise. While there is evidence of a link between the two diseases, the pathophysiological mechanisms they share are not fully understood.
Humans Diabetes Mellitus, Type 2 Pulmonary Disease, Chronic Obstructive Machine Learning Matrix Metalloproteinase 9 Computational Biology Gene Expression Profiling Laminin Biomarkers ROC Curve
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6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression.

Anais da Academia Brasileira de Ciencias Jan 1, 2017
6-Gingerol is the major active constituent of ginger. In the current study, we aimed to investigate the mechanisms underlying the effects of 6-Gingerol on hair growth. Mice were randomly divided into five groups; after hair depilation (day 0), mice w...
Hair Follicle Fatty Alcohols Mice, Inbred C57BL Enzyme Induction Mice Transforming Growth Factor beta Female Catechols Fibroblast Growth Factor 7 Insulin-Like Growth Factor I Matrix Metalloproteinase 9 Animals Random Allocation Matrix Metalloproteinase 2 Plant Extracts Male Vascular Endothelial Growth Factor A
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Serum Level of Matrix Metalloproteinase-9 in Patients with Head and Neck Squamous Cell Carcinoma.

Clinical laboratory Aug 1, 2016
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is characterized by the upregulation of a large number of matrix metalloproteinases (MMPs). The aim of the study was to investigate the level of MMP-9 in the sera of HNSCC patients and its rel...
Head and Neck Neoplasms Humans Neoplasm Staging Female Biomarkers, Tumor Matrix Metalloproteinase 9 Aged Carcinoma, Squamous Cell Male Aged, 80 and over Adult Middle Aged Squamous Cell Carcinoma of Head and Neck
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