AIMC Topic: RNA, Messenger

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Metformin Alleviates Lipopolysaccharide-induced Acute Lung Injury through Suppressing Toll-like Receptor 4 Signaling.

Iranian journal of allergy, asthma, and immunology Dec 1, 2016
Signaling AMP-activated protein kinase (AMPK), an energy sensing enzyme, has been implicated in controlling inflammation. In this study we investigated whether activation of AMPK by metformin could protect the lung from lipopolysaccharide (LPS)-induc...
Lipopolysaccharides Real-Time Polymerase Chain Reaction Myeloid Differentiation Factor 88 Blotting, Western RNA, Messenger Tumor Necrosis Factor-alpha Toll-Like Receptor 4 NF-kappa B Rats, Wistar Peroxidase AMP-Activated Protein Kinases Rats Animals Metformin Acute Lung Injury Hypoglycemic Agents Male Lung
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Genome wide predictions of miRNA regulation by transcription factors.

Bioinformatics (Oxford, England) Sep 1, 2016
MOTIVATION: Reconstructing regulatory networks from expression and interaction data is a major goal of systems biology. While much work has focused on trying to experimentally and computationally determine the set of transcription-factors (TFs) and m...
Gene Expression Profiling Gene Regulatory Networks RNA, Messenger Transcription Factors Humans MicroRNAs Machine Learning
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Schwann Cell and Axon: An Interlaced Unit-From Action Potential to Phenotype Expression.

Advances in experimental medicine and biology Jan 1, 2016
Here we propose a model of a peripheral axon with a great deal of autonomy from its cell body-the autonomous axon-but with a substantial dependence on its ensheathing Schwann cell (SC), the axon-SC unit. We review evidence in several fields and show ...
Animals RNA, Messenger Rats Signal Transduction Action Potentials Humans Neural Networks, Computer Phenotype Microtubules Biological Transport Nerve Regeneration Exosomes Ribosomes Cell Communication Schwann Cells Axons Sural Nerve
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Intraoperative Diagnosis Support Tool for Serous Ovarian Tumors Based on Microarray Data Using Multicategory Machine Learning.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Jan 1, 2016
OBJECTIVES: Serous borderline ovarian tumors (SBOTs) are a subtype of serous ovarian carcinoma with atypical proliferation. Frozen-section diagnosis has been used as an intraoperative diagnosis tool in supporting the fertility-sparing surgery by diag...
Ovarian Neoplasms Predictive Value of Tests Blotting, Western Neoplasm Staging Carcinoma, Ovarian Epithelial RNA, Messenger Gene Expression Regulation, Neoplastic Support Vector Machine Databases, Genetic Immunoenzyme Techniques Neoplasms, Glandular and Epithelial Cystadenocarcinoma, Serous Humans Machine Learning Prognosis Female Biomarkers, Tumor Survival Rate Gene Expression Profiling Monitoring, Intraoperative Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction
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[Study of FN1 and ZNF438 gene expression negatively regulated by androgen receptor in androgen-independent LNCaP cells].

Zhonghua yi xue za zhi Dec 19, 2015
OBJECTIVE: To verify whether FN1 and ZNF438 are the androgen receptor(AR) target genes in LNCaP-AI cells and investigate the effects of AR exerts on FN1 and ZNF438 gene expression.
Receptors, Androgen Oligonucleotide Array Sequence Analysis Repressor Proteins Androgens Dihydrotestosterone Gene Expression Blotting, Western Prostatic Neoplasms Male Fibronectins Cell Line, Tumor Humans Down-Regulation RNA, Messenger Gene Expression Regulation, Neoplastic
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LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns.

Oncotarget Nov 24, 2015
Accumulating evidences suggest that long non-coding RNAs (lncRNAs) perform important functions. Genome-wide chromatin-states area rich source of information about cellular state, yielding insights beyond what is typically obtained by transcriptome pr...
Promoter Regions, Genetic Lysine K562 Cells Histones Gene Ontology Cell Line RNA, Long Noncoding HeLa Cells Methylation Chromatin Transcription Initiation Site Humans Algorithms Cells, Cultured Neoplasms Gene Expression Profiling Cell Line, Tumor Gene Regulatory Networks RNA, Messenger Models, Genetic Hep G2 Cells
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[Role and mechanism of the NOD-like receptor 3 inflammasome in ventilator-induced lung injury in rats].

Zhonghua wei zhong bing ji jiu yi xue Oct 1, 2015
OBJECTIVE: To investigate the role and its mechanism of the NOD-like receptor 3 (NLRP3) inflammasome in alveolar macrophages in ventilator-induced lung injury (VILI) in rats.
Rats Rats, Sprague-Dawley Bronchoalveolar Lavage Fluid Carrier Proteins NF-kappa B Male Animals Tidal Volume Caspase 1 NLR Family, Pyrin Domain-Containing 3 Protein Respiration, Artificial Interleukin-1beta Interleukin-18 Macrophages, Alveolar Lung Inflammasomes Ventilator-Induced Lung Injury RNA, Messenger Random Allocation
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Effect of Mast Cell Chymase on Activation, Proliferation and Transdifferentiation of Hepatic Stellate Cells.

Hepato-gastroenterology Jun 1, 2015
BACKGROUND/AIMS: This work aims to observe the effects of mast cell (MC) chymase on activation, proliferation and transdifferentiation of hepatic stellate cells (HSCs) and to discuss the role of chymase in development of liver fibrosis.
Cells, Cultured Animals Male Real-Time Polymerase Chain Reaction RNA, Messenger Cell Transdifferentiation Chymases Blotting, Western Rats, Wistar Transforming Growth Factor beta1 Rats Hepatic Stellate Cells Cell Proliferation Actins Mast Cells Collagen Type I
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Doxorubicin enhances (131)I-rituximab induced cell death in Raji cells.

Journal of cancer research and therapeutics Jan 1, 2015
AIM: There are various therapeutic modalities of treatment for non-Hodgkin's lymphoma, but with certain limitations, hence, investigating the scope of combined therapeutic approach.
Tumor Cells, Cultured Rituximab Radiopharmaceuticals Poly(ADP-ribose) Polymerases Doxorubicin Burkitt Lymphoma Iodine Radioisotopes Radiation-Sensitizing Agents Drug Synergism Humans RNA, Messenger Signal Transduction Cell Proliferation Antineoplastic Combined Chemotherapy Protocols Apoptosis Blotting, Western Flow Cytometry
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