AIMC Topic: Signal Transduction

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Commercial glucometer as signal transducer for simple evaluation of DNA methyltransferase activity and inhibitors screening.

Analytica chimica acta Nov 23, 2017
DNA methyltransferase (MTase) plays an important role in many biological processes and has been recognized as a predictive cancer biomarker far before other signs of malignancy and a therapeutic target in cancer treatment. Thus simple and sensitive d...
Signal Transduction DNA Methylation Limit of Detection Humans Antineoplastic Agents Biosensing Techniques Equipment Design Drug Evaluation, Preclinical Blood Glucose Self-Monitoring Enzyme Inhibitors Enzyme Assays DNA-Cytosine Methylases
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Predicting pathogenic genes for primary myelofibrosis based on a system‑network approach.

Molecular medicine reports Oct 20, 2017
The aim of the present study was to predict pathogenic genes for primary myelofibrosis (PMF) using a system‑network approach by combining protein‑protein interaction (PPI) network and gene expression data with known pathogenic genes. PMF gene express...
Humans Neural Networks, Computer Gene Expression Profiling Computational Biology Signal Transduction Models, Biological Primary Myelofibrosis Gene Regulatory Networks Genetic Predisposition to Disease Genetic Association Studies
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A support vector machine classifier for the prediction of osteosarcoma metastasis with high accuracy.

International journal of molecular medicine Sep 7, 2017
In this study, gene expression profiles of osteosarcoma (OS) were analyzed to identify critical genes associated with metastasis. Five gene expression datasets were screened and downloaded from Gene Expression Omnibus (GEO). Following assessment by M...
Protein Interaction Mapping Bone Neoplasms Neoplasm Staging Neoplasm Metastasis Reproducibility of Results Gene Expression Profiling Protein Interaction Maps Support Vector Machine Osteosarcoma Gene Expression Regulation, Neoplastic Signal Transduction Humans
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Prediction and analysis of essential genes using the enrichments of gene ontology and KEGG pathways.

PloS one Sep 5, 2017
Identifying essential genes in a given organism is important for research on their fundamental roles in organism survival. Furthermore, if possible, uncovering the links between core functions or pathways with these essential genes will further help ...
Gene Ontology Reproducibility of Results Signal Transduction Support Vector Machine Genes, Essential
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Finding disagreement pathway signatures and constructing an ensemble model for cancer classification.

Scientific reports Aug 30, 2017
Cancer classification based on molecular level is a relatively routine research procedure with advances in high-throughput molecular profiling techniques. However, the number of genes typically far exceeds the number of the sample size in gene expres...
Support Vector Machine Neoplasm Proteins Datasets as Topic Oligonucleotide Array Sequence Analysis Gene Regulatory Networks Gene Expression Regulation, Neoplastic Signal Transduction Taxoids Atlases as Topic Anthracyclines Antineoplastic Agents Gene Expression Profiling Humans Neoplasms
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Bow-tie signaling in c-di-GMP: Machine learning in a simple biochemical network.

PLoS computational biology Aug 2, 2017
Bacteria of many species rely on a simple molecule, the intracellular secondary messenger c-di-GMP (Bis-(3'-5')-cyclic dimeric guanosine monophosphate), to make a vital choice: whether to stay in one place and form a biofilm, or to leave it in search...
Machine Learning Phenotype Biofilms Computational Biology Signal Transduction Pseudomonas aeruginosa Cell Movement Cyclic GMP Models, Biological
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Mapping quorum sensing onto neural networks to understand collective decision making in heterogeneous microbial communities.

Physical biology Jul 19, 2017
Microbial communities frequently communicate via quorum sensing (QS), where cells produce, secrete, and respond to a threshold level of an autoinducer (AI) molecule, thereby modulating gene expression. However, the biology of QS remains incompletely ...
Bacterial Physiological Phenomena Quorum Sensing Gene Expression Regulation, Bacterial Bacterial Proteins Models, Biological Microbial Interactions Signal Transduction Staphylococcus aureus Decision Making Neural Networks, Computer
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A knowledge-based T2-statistic to perform pathway analysis for quantitative proteomic data.

PLoS computational biology Jun 16, 2017
Approaches to identify significant pathways from high-throughput quantitative data have been developed in recent years. Still, the analysis of proteomic data stays difficult because of limited sample size. This limitation also leads to the practice o...
Models, Statistical Data Interpretation, Statistical Models, Biological Knowledge Bases Proteomics Proteome Signal Transduction Algorithms Computer Simulation
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Data mining and pathway analysis of glucose-6-phosphate dehydrogenase with natural language processing.

Molecular medicine reports Jun 15, 2017
Human glucose-6-phosphate dehydrogenase (G6PD) is a crucial enzyme in the pentose phosphate pathway, and serves an important role in biosynthesis and the redox balance. G6PD deficiency is a major cause of neonatal jaundice and acute hemolyticanemia, ...
Glucosephosphate Dehydrogenase Humans Metabolic Networks and Pathways Signal Transduction Gene Regulatory Networks Glucosephosphate Dehydrogenase Deficiency Data Mining MicroRNAs Gene Ontology Natural Language Processing
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Prediction of synergistic anti-cancer drug combinations based on drug target network and drug induced gene expression profiles.

Artificial intelligence in medicine Jun 3, 2017
OBJECTIVE: Synergistic drug combinations are promising therapies for cancer treatment. However, effective prediction of synergistic drug combinations is quite challenging as mechanisms of drug synergism are still unclear. Various features such as dru...
Artificial Intelligence Computer Simulation Humans Computational Biology Gene Expression Regulation, Neoplastic Signal Transduction Drug Synergism Transcriptome Antineoplastic Combined Chemotherapy Protocols Pharmacogenetics Reproducibility of Results Databases, Genetic Protein Interaction Maps Neoplasms Gene Regulatory Networks Gene Expression Profiling
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