AIMC Topic: Signal Transduction

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RNA-seq analysis reveals different gene ontologies and pathways in rheumatoid arthritis and Kashin-Beck disease.

International journal of rheumatic diseases Sep 5, 2018
AIMS: To understand the pathogenesis of cartilage damage in Kashin-Beck disease (KBD) and rheumatoid arthritis (RA) which similar clinical symptoms.
Aged Male Middle Aged Gene Regulatory Networks Arthritis, Rheumatoid Humans Phenotype Female RNA Inflammation Mediators Cartilage Gene Ontology Kashin-Beck Disease Genetic Predisposition to Disease Sequence Analysis, RNA Signal Transduction Databases, Genetic Proteoglycans
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Identification of novel immune-relevant drug target genes for Alzheimer's Disease by combining ontology inference with network analysis.

CNS neuroscience & therapeutics Aug 14, 2018
AIMS: Alzheimer's disease (AD) is one of the leading causes of death in elderly people. Its pathogenesis is greatly associated with the abnormality of immune system. However, only a few immune-relevant AD drug target genes have been discovered up to ...
Databases, Factual Gene Ontology Drug Delivery Systems Animals Gene Expression Profiling Gene Regulatory Networks Genetic Predisposition to Disease Signal Transduction Alzheimer Disease Antipsychotic Agents Humans
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Machine learning approaches infer vitamin D signaling: Critical impact of vitamin D receptor binding within topologically associated domains.

The Journal of steroid biochemistry and molecular biology Jul 22, 2018
The vitamin D-modulated transcriptome of highly responsive human cells, such as THP-1 monocytes, comprises more than 500 genes, half of which are primary targets. Recently, we proposed a chromatin model of vitamin D signaling demonstrating that nearl...
Machine Learning Algorithms Protein Binding RNA, Messenger Signal Transduction Humans High-Throughput Nucleotide Sequencing Gene Expression Regulation Chromatin CCCTC-Binding Factor Vitamin D Receptors, Calcitriol Cell Line THP-1 Cells
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Computational Approach to Investigating Key GO Terms and KEGG Pathways Associated with CNV.

BioMed research international Apr 11, 2018
Choroidal neovascularization (CNV) is a severe eye disease that leads to blindness, especially in the elderly population. Various endogenous and exogenous regulatory factors promote its pathogenesis. However, the detailed molecular biological mechani...
Humans Computational Biology Signal Transduction Neurons Gene Ontology Choroidal Neovascularization
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Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical- Approach Combining Experiments and Machine Learning.

Frontiers in immunology Mar 20, 2018
Life-threatening cardiomyopathy is a severe, but common, complication associated with severe trauma or sepsis. Several signaling pathways involved in apoptosis and necroptosis are linked to trauma- or sepsis-associated cardiomyopathy. However, the un...
Cytochromes c Receptor-Interacting Protein Serine-Threonine Kinases Signal Transduction Apoptosis Caspase 3 Algorithms Myocytes, Cardiac Heparitin Sulfate Cells, Cultured Humans Cell Culture Techniques Animals Necrosis Machine Learning Sepsis Cardiomyopathies Mice Wounds and Injuries
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Design and validation of an ontology-driven animal-free testing strategy for developmental neurotoxicity testing.

Toxicology and applied pharmacology Mar 13, 2018
Developmental neurotoxicity entails one of the most complex areas in toxicology. Animal studies provide only limited information as to human relevance. A multitude of alternative models have been developed over the years, providing insights into mech...
Neurons Biological Ontologies Toxicology Models, Animal Toxicity Tests Reproducibility of Results Animals Risk Assessment Signal Transduction Animal Testing Alternatives Neurogenesis Neurotoxicity Syndromes Humans Cells, Cultured Brain
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Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive Immune Repertoires.

Frontiers in immunology Feb 21, 2018
The adaptive immune system recognizes antigens an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in...
Signal Transduction Data Interpretation, Statistical Autoimmune Diseases High-Throughput Nucleotide Sequencing Receptors, Immunologic Adaptive Immunity Software Animals Neoplasms HIV Infections Computational Biology Humans Machine Learning
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Simvastatin and nanofibrous poly(l-lactic acid) scaffolds to promote the odontogenic potential of dental pulp cells in an inflammatory environment.

Acta biomaterialia Dec 30, 2017
UNLABELLED: In this study, we investigated the anti-inflammatory, odontogenic and pro-angiogenic effects of integrating simvastatin and nanofibrous poly(l-lactic acid) (NF-PLLA) scaffolds on dental pulp cells (DPCs). Highly porous NF-PLLA scaffolds t...
Human Umbilical Vein Endothelial Cells Nanofibers Alkaline Phosphatase Odontogenesis Inflammation Mesenchymal Stem Cells Signal Transduction Neovascularization, Physiologic Polyesters Lipopolysaccharides Humans Gene Expression Regulation Dental Pulp Tissue Scaffolds Cell Differentiation Biomarkers Simvastatin Young Adult Cytoprotection RNA, Messenger
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The Interplay Between Epithelial-Mesenchymal Transition (EMT) and the Thyroid Hormones-αvβ3 Axis in Ovarian Cancer.

Hormones & cancer Dec 19, 2017
Ovarian cancer is a highly metastatic disease. The metastatic potential is enhanced by epithelial to mesenchymal transition (EMT) in which αvβ3 integrin plays a role. Thyroid hormones (L-thyroxine, T4, and 3,5,3'-triiodo-L-thyronine, T3) bind this in...
Triiodothyronine Humans Epithelial-Mesenchymal Transition beta Catenin Zinc Finger E-box-Binding Homeobox 1 Gene Expression Regulation, Neoplastic Thyroxine Female Integrin alphaVbeta3 Signal Transduction Cell Line, Tumor Cadherins Snail Family Transcription Factors Ovarian Neoplasms Thyroid Hormones Zonula Occludens-1 Protein Vimentin
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Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor κB ligand-induced NF-κB pathway.

Biochemical and biophysical research communications Dec 18, 2017
Linarin, a natural flavonoid glycoside widely found in plants, has been reported to possess anti-inflammation, neuroprotection and osteogenic properties. However, its impact on osteoclast remains unclear. In the present study, the effects of linarin ...
Animals Mice Signal Transduction RANK Ligand Osteoblasts Cells, Cultured Dose-Response Relationship, Drug Mice, Inbred C57BL Glycosides Macrophages NF-kappa B Osteogenesis RAW 264.7 Cells
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