AIMC Topic: Case-Control Studies

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High rates of atherogenic dyslipidemia, β-cell function loss, and microangiopathy among Turkish migrants with T2DM.

Diabetes & metabolic syndrome
AIMS: Non-Caucasian migrants require dedicated approaches in diabetes management due to specific genetic; socio-cultural; demographic and anthropological determinants. Documenting such phenotypes allows for better understanding unmet needs and manage...

Supervised machine learning to decipher the complex associations between neuro-immune biomarkers and quality of life in schizophrenia.

Metabolic brain disease
Stable phase schizophrenia is characterized by altered patterning in tryptophan catabolites (TRYCATs) and memory impairments, which are associated with PHEMN (psychosis, hostility, excitation, mannerism and negative) and DAPS (depression, anxiety and...

Automated assessment of breast cancer margin in optical coherence tomography images via pretrained convolutional neural network.

Journal of biophotonics
The benchmark method for the evaluation of breast cancers involves microscopic testing of a hematoxylin and eosin (H&E)-stained tissue biopsy. Resurgery is required in 20% to 30% of cases because of incomplete excision of malignant tissues. Therefore...

Predicting chemo-brain in breast cancer survivors using multiple MRI features and machine-learning.

Magnetic resonance in medicine
PURPOSE: Breast cancer (BC) is the most common cancer in women worldwide. There exist various advanced chemotherapy drugs for BC; however, chemotherapy drugs may result in brain damage during treatment. When a patient's brain is changed in response t...

The association between serum uric acid to creatinine ratio and renal disease progression in type 2 diabetic patients in Chinese communities.

Journal of diabetes and its complications
AIMS: Serum uric acid (UA) increases in patients with kidney disease due to the impaired UA clearance. The present study sought to evaluate the association between UA/creatinine ratio (UA/Cr) and renal disease progression in patients with type 2 diab...

Serum adipocytokines are associated with microalbuminuria in patients with type 1 diabetes and incipient chronic complications.

Diabetes & metabolic syndrome
AIMS: Recent studies have implicated possible contribution of adipocytokines in development and progression of microvascular complications in patients with type 1 diabetes (T1DM). The aim of our study was to investigate relationship between adipocyto...

Circulating betatrophin in relation to metabolic, inflammatory parameters, and oxidative stress in patients with type 2 diabetes mellitus.

Diabetes & metabolic syndrome
AIMS: Recently, it was suggested that betatrophin has a role in controlling pancreatic β cell proliferation and lipid metabolism, however, its role in human subjects has not been established yet. The predicting role of betatrophin and MDA along with ...

EEG may serve as a biomarker in Huntington's disease using machine learning automatic classification.

Scientific reports
Reliable markers measuring disease progression in Huntington's disease (HD), before and after disease manifestation, may guide a therapy aimed at slowing or halting disease progression. Quantitative electroencephalography (qEEG) may provide a quantif...

Increased risk of group B Streptococcus causing meningitis in infants with mannose-binding lectin deficiency.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
OBJECTIVES: To evaluate the association of mannose-binding lectin (MBL) deficiency with susceptibility and clinical features of group B Streptococcus (GBS) causing meningitis in Chinese infants.

Identification of Novel Genes in Human Airway Epithelial Cells associated with Chronic Obstructive Pulmonary Disease (COPD) using Machine-Based Learning Algorithms.

Scientific reports
The aim of this project was to identify candidate novel therapeutic targets to facilitate the treatment of COPD using machine-based learning (ML) algorithms and penalized regression models. In this study, 59 healthy smokers, 53 healthy non-smokers an...