AIMC Topic: NF-kappa B

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Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor κB ligand-induced NF-κB pathway.

Biochemical and biophysical research communications Dec 18, 2017
Linarin, a natural flavonoid glycoside widely found in plants, has been reported to possess anti-inflammation, neuroprotection and osteogenic properties. However, its impact on osteoclast remains unclear. In the present study, the effects of linarin ...
Glycosides Dose-Response Relationship, Drug NF-kappa B Osteogenesis RAW 264.7 Cells Osteoblasts Animals Mice Signal Transduction RANK Ligand Mice, Inbred C57BL Cells, Cultured Macrophages
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Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1-Stimulated Chondrocytes by Regulation of MMPs/TIMP-1 Ratio and Type II Collagen Expression via Suppression of NF-B Pathway.

BioMed research international Dec 3, 2017
BACKGROUND: Garlic-derived S-allylmercaptocysteine (SAMC) has widely been used in many disease therapies. However, the potential effects and mechanism of SAMC on IL-1-stimulated chondrocytes are unclear.
Chondrocytes Humans Osteoarthritis Matrix Metalloproteinases Transcription Factor RelA Garlic Tumor Necrosis Factor-alpha Cysteine Collagen Type II Signal Transduction Tissue Inhibitor of Metalloproteinase-1 Interleukin-1beta Gene Expression NF-kappa B
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Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of Cinnamomum osmophloeum Kanehira in endotoxin-induced mice.

Journal of food and drug analysis Apr 19, 2017
Cinnamomum osmophloeum Kanehira is a Taiwan native plant that belongs to genus Cinnamomum and is also known as pseudocinnamomum or indigenous cinnamon. Its leaf is traditionally used by local people in cooking and as folk therapy. We previously demon...
Signal Transduction Plant Leaves NF-kappa B Male Anti-Inflammatory Agents Humans Inflammation Mediators NLR Family, Pyrin Domain-Containing 3 Protein Oils, Volatile Acrolein Cytokines Mice Cinnamomum Biomarkers Plant Extracts Endotoxins Animals Inflammation
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Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro.

The Kaohsiung journal of medical sciences Dec 30, 2016
Achyranthes bidentate Blume (Niuxi) is often employed for treatment of arthritis in Traditional Chinese Medicine and possesses anti-inflammatory properties. Phytochemical and pharmacological studies proved the oleanane-type saponins to be the main bi...
Matrix Metalloproteinase 3 Primary Cell Culture Achyranthes bcl-Associated Death Protein bcl-X Protein Animals Male NF-kappa B Apoptosis Matrix Metalloproteinase 9 bcl-2-Associated X Protein Caspase 3 Chondrocytes Tumor Suppressor Protein p53 Plant Extracts Anti-Inflammatory Agents, Non-Steroidal Saponins Gene Expression Regulation Rats Plant Roots Proliferating Cell Nuclear Antigen Inflammation Interleukin-1beta Cyclooxygenase 2 Signal Transduction Cartilage, Articular Rats, Sprague-Dawley
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INHIBITORY ACTIVITY OF MANGIFERIN ON PYLORI-INDUCED INFLAMMATION IN HUMAN GASTRIC CARCINOMA AGS CELLS.

African journal of traditional, complementary, and alternative medicines : AJTCAM Nov 23, 2016
BACKGROUND: Gastric cancer is a serious health issue caused by and claims more lives in developing and undeveloped countries. Hence, the need for a natural drug with several pharmacological activities with no adverse effect are highly recommended. T...
Interleukin-1beta Interleukin-8 NF-kappa B Anti-Inflammatory Agents Carcinoma Helicobacter Infections Helicobacter pylori Xanthones Humans Tumor Necrosis Factor-alpha Stomach Neoplasms Cell Line, Tumor
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Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells.

Oxidative medicine and cellular longevity Dec 28, 2015
Hericium erinaceus (HE) is an edible mushroom that has been shown to exhibit anticancer and anti-inflammatory activities. We investigated the antiangiogenic and antioxidant potentials of ethanol extracts of HE in human endothelial (EA.hy926) cells up...
Humans Neovascularization, Pathologic Heme Oxygenase-1 Reactive Oxygen Species Tumor Necrosis Factor-alpha Glutathione NF-kappa B Antioxidants NF-E2-Related Factor 2 Basidiomycota Anti-Inflammatory Agents Inflammation Angiogenesis Inducing Agents Endothelial Cells Matrix Metalloproteinase 9 Signal Transduction Intercellular Adhesion Molecule-1 Angiogenesis Inhibitors
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Exopolysaccharides of Lactobacillus reuteri: Their influence on adherence of E. coli to epithelial cells and inflammatory response.

Carbohydrate polymers Dec 17, 2015
The aim of the study was to characterize exopolysaccharides (EPS) originated from Lactobacillus reuteri strain DSM 17938 (EPS-DSM17938) and L. reuteri strain L26 Biocenol™ (EPS-L26) and evaluate their influence on adherence of enterotoxigenic Escheri...
Interleukin-6 Animals Swine RNA, Messenger Cell Line Tumor Necrosis Factor-alpha Up-Regulation Glucans Enterotoxigenic Escherichia coli Limosilactobacillus reuteri Epithelial Cells Interleukin-1beta NF-kappa B Polysaccharides, Bacterial Bacterial Adhesion
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Comparative evaluation of different cultivars of Flos Chrysanthemi by an anti-inflammatory-based NF-κB reporter gene assay coupled to UPLC-Q/TOF MS with PCA and ANN.

Journal of ethnopharmacology Aug 29, 2015
ETHNOPHARMACOLOGICAL RELEVANCE: Flos Chrysanthemi (FC), a commonly used traditional Chinese medicine, has five major cultivars ("Boju", "Chuju", "Gongju", "Hangbaiju" and "Huaiju") from different sources. However, the active constituents of these cul...
HEK293 Cells Genes, Reporter Chrysanthemum NF-kappa B Anti-Inflammatory Agents Drug Evaluation, Preclinical Humans Chromatography, High Pressure Liquid Neural Networks, Computer Tandem Mass Spectrometry Principal Component Analysis
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Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways.

Environmental toxicology May 26, 2015
Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially ...
Benzhydryl Compounds Cell Migration Assays, Macrophage Chemotaxis, Leukocyte Diethylhexyl Phthalate Female Middle Aged Estradiol Inflammation Signal Transduction Cell Movement Lipopolysaccharides Phenols Interleukin-1beta NF-kappa B Humans Tumor Necrosis Factor-alpha Cells, Cultured Macrophages Cytokines
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Exploration of Active Substances and Its Potential Mechanism of Gancao Fuzi Decoction on Inflammatory Based on Metabolomics and Network Pharmacology.

Rapid communications in mass spectrometry : RCM May 30, 2025
Gancao Fuzi decoction (GCFZT) is a traditional Chinese formula, which has been commonly used in clinical practice to treat inflammatory diseases. However, the active substance of GCFZT in the treatment of inflammation is not fully clarified. In this ...
Animals Mice Anti-Inflammatory Agents Chromatography, High Pressure Liquid Tandem Mass Spectrometry RAW 264.7 Cells Network Pharmacology Inflammation Signal Transduction Metabolomics Drugs, Chinese Herbal NF-kappa B
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