AIMC Topic: NF-kappa B

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Effects of docosahexaenoic acid on locomotor activity in ethanol-treated HIV-1 transgenic rats.

Journal of neurovirology Dec 19, 2017
Binge drinking affects the onset and progression of human immunodeficiency virus (HIV)-associated neurological disorders. The HIV-1 transgenic (HIV-1Tg) rat was created with a gag- and pol-deleted HIV-1 viral genome to mimic HIV-infected patients rec...
Gene Expression NF-kappa B Interleukin-18 HIV-1 Docosahexaenoic Acids Locomotion Corpus Striatum Endotoxins Binge Drinking Rats, Inbred F344 Animals Male HIV Infections Maze Learning Rats Rats, Transgenic Disease Models, Animal Interleukin-6
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Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor κB ligand-induced NF-κB pathway.

Biochemical and biophysical research communications Dec 18, 2017
Linarin, a natural flavonoid glycoside widely found in plants, has been reported to possess anti-inflammation, neuroprotection and osteogenic properties. However, its impact on osteoclast remains unclear. In the present study, the effects of linarin ...
Osteogenesis RAW 264.7 Cells Osteoblasts Glycosides Mice Cells, Cultured Mice, Inbred C57BL Signal Transduction Macrophages Dose-Response Relationship, Drug RANK Ligand Animals NF-kappa B
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Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1-Stimulated Chondrocytes by Regulation of MMPs/TIMP-1 Ratio and Type II Collagen Expression via Suppression of NF-B Pathway.

BioMed research international Dec 3, 2017
BACKGROUND: Garlic-derived S-allylmercaptocysteine (SAMC) has widely been used in many disease therapies. However, the potential effects and mechanism of SAMC on IL-1-stimulated chondrocytes are unclear.
Osteoarthritis Matrix Metalloproteinases Transcription Factor RelA Humans Collagen Type II Signal Transduction Cysteine Tumor Necrosis Factor-alpha Tissue Inhibitor of Metalloproteinase-1 Interleukin-1beta Garlic Gene Expression NF-kappa B Chondrocytes
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Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of Cinnamomum osmophloeum Kanehira in endotoxin-induced mice.

Journal of food and drug analysis Apr 19, 2017
Cinnamomum osmophloeum Kanehira is a Taiwan native plant that belongs to genus Cinnamomum and is also known as pseudocinnamomum or indigenous cinnamon. Its leaf is traditionally used by local people in cooking and as folk therapy. We previously demon...
Plant Leaves Acrolein Oils, Volatile Humans NF-kappa B Cinnamomum Cytokines Mice Endotoxins Anti-Inflammatory Agents Biomarkers Plant Extracts NLR Family, Pyrin Domain-Containing 3 Protein Animals Inflammation Inflammation Mediators Male Signal Transduction
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Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro.

The Kaohsiung journal of medical sciences Dec 30, 2016
Achyranthes bidentate Blume (Niuxi) is often employed for treatment of arthritis in Traditional Chinese Medicine and possesses anti-inflammatory properties. Phytochemical and pharmacological studies proved the oleanane-type saponins to be the main bi...
Tumor Suppressor Protein p53 Gene Expression Regulation Proliferating Cell Nuclear Antigen Cyclooxygenase 2 Cartilage, Articular Matrix Metalloproteinase 3 Primary Cell Culture Achyranthes bcl-Associated Death Protein bcl-X Protein NF-kappa B Apoptosis Matrix Metalloproteinase 9 Animals Caspase 3 bcl-2-Associated X Protein Inflammation Anti-Inflammatory Agents, Non-Steroidal Chondrocytes Signal Transduction Plant Roots Saponins Rats, Sprague-Dawley Interleukin-1beta Male Plant Extracts Rats
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INHIBITORY ACTIVITY OF MANGIFERIN ON PYLORI-INDUCED INFLAMMATION IN HUMAN GASTRIC CARCINOMA AGS CELLS.

African journal of traditional, complementary, and alternative medicines : AJTCAM Nov 23, 2016
BACKGROUND: Gastric cancer is a serious health issue caused by and claims more lives in developing and undeveloped countries. Hence, the need for a natural drug with several pharmacological activities with no adverse effect are highly recommended. T...
Carcinoma Helicobacter Infections Helicobacter pylori Xanthones Cell Line, Tumor Interleukin-1beta Humans Interleukin-8 Tumor Necrosis Factor-alpha NF-kappa B Stomach Neoplasms Anti-Inflammatory Agents
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Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells.

Oxidative medicine and cellular longevity Dec 28, 2015
Hericium erinaceus (HE) is an edible mushroom that has been shown to exhibit anticancer and anti-inflammatory activities. We investigated the antiangiogenic and antioxidant potentials of ethanol extracts of HE in human endothelial (EA.hy926) cells up...
Glutathione Basidiomycota Endothelial Cells NF-E2-Related Factor 2 Angiogenesis Inducing Agents Anti-Inflammatory Agents Matrix Metalloproteinase 9 Intercellular Adhesion Molecule-1 Neovascularization, Pathologic Humans Heme Oxygenase-1 Tumor Necrosis Factor-alpha Angiogenesis Inhibitors Reactive Oxygen Species NF-kappa B Antioxidants Inflammation Signal Transduction
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Exopolysaccharides of Lactobacillus reuteri: Their influence on adherence of E. coli to epithelial cells and inflammatory response.

Carbohydrate polymers Dec 17, 2015
The aim of the study was to characterize exopolysaccharides (EPS) originated from Lactobacillus reuteri strain DSM 17938 (EPS-DSM17938) and L. reuteri strain L26 Biocenol™ (EPS-L26) and evaluate their influence on adherence of enterotoxigenic Escheri...
Tumor Necrosis Factor-alpha Interleukin-6 Glucans Enterotoxigenic Escherichia coli Limosilactobacillus reuteri Interleukin-1beta NF-kappa B Polysaccharides, Bacterial Bacterial Adhesion Up-Regulation Animals Swine RNA, Messenger Cell Line Epithelial Cells
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Comparative evaluation of different cultivars of Flos Chrysanthemi by an anti-inflammatory-based NF-κB reporter gene assay coupled to UPLC-Q/TOF MS with PCA and ANN.

Journal of ethnopharmacology Aug 29, 2015
ETHNOPHARMACOLOGICAL RELEVANCE: Flos Chrysanthemi (FC), a commonly used traditional Chinese medicine, has five major cultivars ("Boju", "Chuju", "Gongju", "Hangbaiju" and "Huaiju") from different sources. However, the active constituents of these cul...
Drug Evaluation, Preclinical Chromatography, High Pressure Liquid Tandem Mass Spectrometry Humans HEK293 Cells Neural Networks, Computer Genes, Reporter Principal Component Analysis Chrysanthemum NF-kappa B Anti-Inflammatory Agents
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Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways.

Environmental toxicology May 26, 2015
Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially ...
Female Middle Aged Estradiol Inflammation Signal Transduction Humans Tumor Necrosis Factor-alpha Cells, Cultured Macrophages Cytokines Benzhydryl Compounds Cell Migration Assays, Macrophage Chemotaxis, Leukocyte Diethylhexyl Phthalate Cell Movement Lipopolysaccharides Phenols Interleukin-1beta NF-kappa B
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