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Tumor Suppressor Protein p53

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MRI features predict p53 status in lower-grade gliomas via a machine-learning approach.

NeuroImage. Clinical 29527478
BACKGROUND: P53 mutation status is a pivotal biomarker for gliomas. Here, we developed a machine-learning model to predict p53 status in lower-grade gliomas based on radiomic features extracted from conventional magnetic resonance (MR) images.
Adolescent Adult Aged Brain Neoplasms Child Child, Preschool Female Glioma Humans Image Processing, Computer-Assisted Machine Learning Magnetic Resonance Imaging Male Middle Aged Mutation Retrospective Studies ROC Curve Tumor Suppressor Protein p53 Young Adult
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[Role of high mobility group protein B1 in 
IL-1α-induced endothelial cell senescence].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 29317575
To explore the effect of interleukin-1α (IL-1α) on the senescence of human umbilical vein endothelial cells (HUVECs) and the function of high mobility group protein 1 (HMGB1).
 Methods: HUVECs were randomly divided into a control group, a IL-1α group...
beta-Galactosidase Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinase Inhibitor p21 HMGB1 Protein Human Umbilical Vein Endothelial Cells Humans Interleukin-1alpha Random Allocation RNA, Messenger Sirtuin 1 Tumor Suppressor Protein p53
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Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro.

The Kaohsiung journal of medical sciences 28137413
Achyranthes bidentate Blume (Niuxi) is often employed for treatment of arthritis in Traditional Chinese Medicine and possesses anti-inflammatory properties. Phytochemical and pharmacological studies proved the oleanane-type saponins to be the main bi...
Achyranthes Animals Anti-Inflammatory Agents, Non-Steroidal Apoptosis bcl-2-Associated X Protein bcl-Associated Death Protein bcl-X Protein Cartilage, Articular Caspase 3 Chondrocytes Cyclooxygenase 2 Gene Expression Regulation Inflammation Interleukin-1beta Male Matrix Metalloproteinase 3 Matrix Metalloproteinase 9 NF-kappa B Plant Extracts Plant Roots Primary Cell Culture Proliferating Cell Nuclear Antigen Rats Rats, Sprague-Dawley Saponins Signal Transduction Tumor Suppressor Protein p53
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[Effect of jianpi-jiedu formula on tumor angiogenesis-relevant genes expression in colorectal cancer].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 28070042
To investigate the effect of the jianpi-jiedu formula (JPJD) on the expression of angiogenesis-relevant genes in colon cancer.
 Methods: Crude extract was obtained from JPJD by water extract method. The effect of JPJD crude extract on colon cancer ce...
Animals Blotting, Western Cathepsin B Cathepsins Cell Line, Tumor Colorectal Neoplasms Down-Regulation Drugs, Chinese Herbal Gene Expression Profiling Humans Hypoxia-Inducible Factor 1, alpha Subunit Integrin alpha Chains Neovascularization, Pathologic Receptors, Urokinase Plasminogen Activator Signal Transduction Sphingomyelin Phosphodiesterase STAT3 Transcription Factor TOR Serine-Threonine Kinases Tumor Suppressor Protein p53 Up-Regulation Vascular Endothelial Growth Factor A
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Lung cancer prediction using neural network ensemble with histogram of oriented gradient genomic features.

TheScientificWorldJournal 25802891
This paper reports an experimental comparison of artificial neural network (ANN) and support vector machine (SVM) ensembles and their "nonensemble" variants for lung cancer prediction. These machine learning classifiers were trained to predict lung c...
Biomarkers, Tumor Carcinoma, Non-Small-Cell Lung ErbB Receptors Humans Lung Neoplasms Mutation Neural Networks, Computer Proto-Oncogene Proteins p21(ras) Support Vector Machine Tumor Suppressor Protein p53
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Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach.

Environmental and molecular mutagenesis 26764165
Several endpoints associated with cellular responses to DNA damage as well as overt cytotoxicity were multiplexed into a miniaturized, "add and read" type flow cytometric assay. Reagents included a detergent to liberate nuclei, RNase and propidium io...
Algorithms Aneugens Automation, Laboratory Biomarkers Cell Line DNA Damage Flow Cytometry Histones Humans Machine Learning Mutagenicity Tests Mutagens Reproducibility of Results Tumor Suppressor Protein p53
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From word models to executable models of signaling networks using automated assembly.

Molecular systems biology 29175850
Word models (natural language descriptions of molecular mechanisms) are a common currency in spoken and written communication in biomedicine but are of limited use in predicting the behavior of complex biological networks. We present an approach to b...
Antineoplastic Agents Cell Line, Tumor Computer Simulation DNA Damage Drug Resistance, Neoplasm Enzyme Inhibitors Gene Expression Regulation, Neoplastic Humans Indoles Language Melanoma Models, Genetic Natural Language Processing Neural Networks, Computer Proto-Oncogene Proteins B-raf Proto-Oncogene Proteins p21(ras) Signal Transduction Skin Neoplasms Sulfonamides Tumor Suppressor Protein p53 Vemurafenib
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Control of Gene Regulatory Networks Using Bayesian Inverse Reinforcement Learning.

IEEE/ACM transactions on computational biology and bioinformatics 29993697
Control of gene regulatory networks (GRNs) to shift gene expression from undesirable states to desirable ones has received much attention in recent years. Most of the existing methods assume that the cost of intervention at each state and time point,...
Algorithms Bayes Theorem Computational Biology Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulatory Networks Humans Machine Learning Melanoma Models, Biological Models, Genetic Proto-Oncogene Proteins c-mdm2 Skin Neoplasms Software Tumor Suppressor Protein p53 Wnt-5a Protein
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