Pulmonary hypertension (PH) is a progressive cardiopulmonary disorder. It features elevated pulmonary arterial pressure, which leads to right ventricular failure and increased mortality. PH's insidious nature, with no specific clinical symptoms, hind...
Type A aortic dissection (TAAD) is a vascular disease with high mortality; however, the role of gene methylation in its pathogenesis has received little attention. This study aimed to identify candidate markers of TAAD by integrating methylation and ...
BACKGROUND: Vascular smooth muscle cells loaded with cholesterol (foam-VSMCs) play a crucial role in the progression of human atherosclerosis. Exchange Protein Directly Activated by cAMP 1 (EPAC1) is a critical protein in the regulation of vascular t...
BACKGROUND: Type II diabetes mellitus (T2DM) is strongly linked with a heightened risk of coronary artery disease (CAD). Exploring biological targets common to T2DM and CAD is essential for CAD intervention strategies.
Here we present a microengineered soft-robotic in vitro platform developed by integrating a pneumatically regulated novel elastomeric actuator with primary culture of human cells. This system is capable of generating dynamic bending motion akin to th...
Angewandte Chemie (International ed. in English)
Dec 23, 2019
Soft organisms such as earthworms can access confined, narrow spaces, inspiring scientists to fabricate soft robots for in vivo manipulation of cells or tissues and minimally invasive surgery. We report a super-soft and super-elastic magnetic DNA hyd...
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
Jun 25, 2019
Sorghum bicolor L. Moench is widely grown all over the world for food and feed. The effects of sorghum extracts on general inflammation have been previously studied, but its anti-vascular inflammatory effects are unknown. Therefore, this study inve...
Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima formation in vein graft failure following coronary artery bypass. However, there are currently no pharmacological interventions that prevent vein graft failure thr...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Nov 30, 2025
Machine learning was employed to annotate images of the thoracic aorta, resulting in the identification of additional thoracic-related targets. However, genetic evaluation of the associations among thoracic aortic traits and their shared genes is lac...
Journal of colloid and interface science
Aug 1, 2025
Coagulation within blood vessels is a major cause of cardiovascular disease and global mortality, highlighting the urgent need for effective anticoagulant strategies. In this study, we introduce a dynamic and highly efficient anticoagulant platform, ...
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