AIMC Topic: Neovascularization, Pathologic

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Micro-morphological feature visualization, auto-classification, and evolution quantitative analysis of tumors by using SR-PCT.

Cancer medicine Mar 7, 2021
Tissue micro-morphological abnormalities and interrelated quantitative data can provide immediate evidences for tumorigenesis and metastasis in microenvironment. However, the multiscale three-dimensional nondestructive pathological visualization, mea...
Synchrotrons Microvessels Intestinal Neoplasms Principal Component Analysis Area Under Curve Neovascularization, Pathologic Specimen Handling X-Ray Microtomography Humans Neural Networks, Computer Machine Learning Tomography, X-Ray Computed Stomach Neoplasms Tumor Microenvironment Liver Neoplasms Liver
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Myricitrin inhibits vascular endothelial growth factor-induced angiogenesis of human umbilical vein endothelial cells and mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Sep 17, 2020
In the present study, the protective effects of myricitrin against vascular endothelial growth factor (VEGF)-induced angiogenesis of vascular endothelial cells were characterized. Cells were induced with 50 ng/mL VEGF in the presence or absence of va...
Human Umbilical Vein Endothelial Cells Vascular Endothelial Growth Factors Humans Mice Xenograft Model Antitumor Assays Caspases Angiogenesis Inhibitors Matrix Metalloproteinases Biomarkers Disease Models, Animal Neovascularization, Pathologic Animals Apoptosis Neovascularization, Physiologic Cell Line, Tumor Flavonoids
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Preoperative identification of microvascular invasion in hepatocellular carcinoma by XGBoost and deep learning.

Journal of cancer research and clinical oncology Aug 27, 2020
PURPOSE: Microvascular invasion (MVI) is a valuable predictor of survival in hepatocellular carcinoma (HCC) patients. This study developed predictive models using eXtreme Gradient Boosting (XGBoost) and deep learning based on CT images to predict MVI...
Humans Retrospective Studies Neovascularization, Pathologic Cohort Studies Microcirculation Liver Neoplasms Carcinoma, Hepatocellular Models, Statistical Disease-Free Survival Female Male Middle Aged Deep Learning
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Artificial neural network models to predict nodal status in clinically node-negative breast cancer.

BMC cancer Jun 21, 2019
BACKGROUND: Sentinel lymph node biopsy (SLNB) is standard staging procedure for nodal status in breast cancer, but lacks therapeutic benefit for patients with benign sentinel nodes. For patients with positive sentinel nodes, individualized surgical s...
Adult Breast Neoplasms Middle Aged Lymph Nodes Lymphatic Metastasis Retrospective Studies Female Aged Aged, 80 and over Young Adult Receptors, Estrogen Sentinel Lymph Node Biopsy Carcinoma, Lobular Axilla Area Under Curve Tumor Burden Neovascularization, Pathologic Linear Models Humans Neural Networks, Computer
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Reinforcement learning-based control of tumor growth under anti-angiogenic therapy.

Computer methods and programs in biomedicine Mar 8, 2019
BACKGROUND AND OBJECTIVES: In recent decades, cancer has become one of the most fatal and destructive diseases which is threatening humans life. Accordingly, different types of cancer treatment are studied with the main aim to have the best treatment...
Angiogenesis Inhibitors Models, Statistical Probability Markov Chains Neovascularization, Pathologic Medical Informatics Endothelial Cells Algorithms Blood Vessels Computer Simulation Humans Neoplasms Machine Learning Time Factors Immunotherapy
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Artificial intelligence for the real-time classification of intrapapillary capillary loop patterns in the endoscopic diagnosis of early oesophageal squamous cell carcinoma: A proof-of-concept study.

United European gastroenterology journal Jan 6, 2019
BACKGROUND: Intrapapillary capillary loops (IPCLs) represent an endoscopically visible feature of early squamous cell neoplasia (ESCN) which correlate with invasion depth - an important factor in the success of curative endoscopic therapy. IPCLs visu...
Esophageal Squamous Cell Carcinoma Humans Artificial Intelligence Esophagoscopy Female Reproducibility of Results Sensitivity and Specificity Male Image Processing, Computer-Assisted Early Detection of Cancer Taiwan Neovascularization, Pathologic
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Deep Learning for Drug Discovery and Cancer Research: Automated Analysis of Vascularization Images.

IEEE/ACM transactions on computational biology and bioinformatics May 29, 2018
Likely drug candidates which are identified in traditional pre-clinical drug screens often fail in patient trials, increasing the societal burden of drug discovery. A major contributing factor to this phenomenon is the failure of traditional in vitro...
Humans Neural Networks, Computer Microscopy Neoplasms Neovascularization, Pathologic Drug Discovery Extracellular Matrix Antineoplastic Agents Pattern Recognition, Automated Deep Learning Cell Culture Techniques Image Processing, Computer-Assisted
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Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells.

Oxidative medicine and cellular longevity Dec 28, 2015
Hericium erinaceus (HE) is an edible mushroom that has been shown to exhibit anticancer and anti-inflammatory activities. We investigated the antiangiogenic and antioxidant potentials of ethanol extracts of HE in human endothelial (EA.hy926) cells up...
NF-kappa B Anti-Inflammatory Agents Matrix Metalloproteinase 9 Intercellular Adhesion Molecule-1 Neovascularization, Pathologic Inflammation Signal Transduction Angiogenesis Inhibitors Reactive Oxygen Species Angiogenesis Inducing Agents Humans Heme Oxygenase-1 Tumor Necrosis Factor-alpha Glutathione Antioxidants Basidiomycota Endothelial Cells NF-E2-Related Factor 2
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Monitoring vascular normalization induced by antiangiogenic treatment with (18)F-fluoromisonidazole-PET.

Molecular oncology Dec 22, 2015
BACKGROUND: Rationalization of antiangiogenics requires biomarkers. Vascular re-normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular...
Pancreas Cell Hypoxia Fluorine Radioisotopes Benzimidazoles Antimetabolites, Antineoplastic Deoxycytidine Gemcitabine Misonidazole Humans Pancreatic Neoplasms Female Breast Breast Neoplasms Positron-Emission Tomography Animals Quinolones Neovascularization, Pathologic Cell Line, Tumor Mice Angiogenesis Inhibitors Mice, Nude
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A machine learning-derived angiogenesis signature for clinical prognosis and immunotherapy guidance in colon adenocarcinoma.

Scientific reports May 31, 2025
Colon adenocarcinoma (COAD) is one of the most prevalent malignancies worldwide and its prognosis is extremely poor. Angiogenesis has been linked to clinical outcomes, tumor progression, and treatment sensitivity. However, the role of angiogenesis in...
Humans Machine Learning Immunotherapy Adenocarcinoma Colonic Neoplasms Neovascularization, Pathologic Prognosis Angiogenesis Female Tumor Microenvironment Biomarkers, Tumor Male
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