AIMC Topic: Cells, Cultured
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Evaluation of machine learning approaches for cell-type identification from single-cell transcriptomics data.
Briefings in bioinformatics
Sep 2, 2021
Single-cell transcriptomics technologies have vast potential in advancing our understanding of cellular heterogeneity in complex tissues. While methods to interpret single-cell transcriptomics data are developing rapidly, challenges in most analysis ...
Deep neural net tracking of human pluripotent stem cells reveals intrinsic behaviors directing morphogenesis.
Stem cell reports
May 11, 2021
Lineage tracing is a powerful tool in developmental biology to interrogate the evolution of tissue formation, but the dense, three-dimensional nature of tissue limits the assembly of individual cell trajectories into complete reconstructions of devel...
3D computational cannula fluorescence microscopy enabled by artificial neural networks.
Optics express
Oct 26, 2020
Computational cannula microscopy (CCM) is a high-resolution widefield fluorescence imaging approach deep inside tissue, which is minimally invasive. Rather than using conventional lenses, a surgical cannula acts as a lightpipe for both excitation and...
The anti-ageing effects of a natural peptide discovered by artificial intelligence.
International journal of cosmetic science
Aug 1, 2020
OBJECTIVE: As skin ages, impaired extracellular matrix (ECM) protein synthesis and increased action of degradative enzymes manifest as atrophy, wrinkling and laxity. There is mounting evidence for the functional role of exogenous peptides across many...
Elucidating the interaction dynamics between microswimmer body and immune system for medical microrobots.
Science robotics
Jun 17, 2020
The structural design parameters of a medical microrobot, such as the morphology and surface chemistry, should aim to minimize any physical interactions with the cells of the immune system. However, the same surface-borne design parameters are also c...
"Living Robots": Ethical Questions About Xenobots.
The American journal of bioethics : AJOB
Jun 1, 2020
Human adipose-derived mesenchymal stem cell-based medical microrobot system for knee cartilage regeneration in vivo.
Science robotics
Jan 22, 2020
Targeted cell delivery by a magnetically actuated microrobot with a porous structure is a promising technique to enhance the low targeting efficiency of mesenchymal stem cell (MSC) in tissue regeneration. However, the relevant research performed to d...
Cell Proliferation
Robotics
Cell Differentiation
Equipment Design
Robotic Surgical Procedures
Cell- and Tissue-Based Therapy
Knee Joint
Mesenchymal Stem Cell Transplantation
Rabbits
Polylactic Acid-Polyglycolic Acid Copolymer
Mesenchymal Stem Cells
Regeneration
Tissue Scaffolds
Microscopy, Electron, Scanning
Electromagnetic Phenomena
Cell Adhesion
Humans
Cartilage, Articular
Cells, Cultured
Animals
DeepTACT: predicting 3D chromatin contacts via bootstrapping deep learning.
Nucleic acids research
Jun 4, 2019
Interactions between regulatory elements are of crucial importance for the understanding of transcriptional regulation and the interpretation of disease mechanisms. Hi-C technique has been developed for genome-wide detection of chromatin contacts. Ho...
A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro.
Toxicological sciences : an official journal of the Society of Toxicology
May 1, 2019
The failure to predict kidney toxicity of new chemical entities early in the development process before they reach humans remains a critical issue. Here, we used primary human kidney cells and applied a systems biology approach that combines multidim...
Anti-hepatofibrosis effect of Allium senescens in activated hepatic stellate cells and thioacetamide-induced fibrosis rat model.
Pharmaceutical biology
Dec 1, 2018
CONTEXT: Allium senescens Linn. (Liliaceae) (ASL) has been traditionally used in Korea and other Asian countries for improving digestive and liver functions.
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