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Cells, Cultured

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Elucidating the interaction dynamics between microswimmer body and immune system for medical microrobots.

Science robotics
The structural design parameters of a medical microrobot, such as the morphology and surface chemistry, should aim to minimize any physical interactions with the cells of the immune system. However, the same surface-borne design parameters are also c...

DeepTACT: predicting 3D chromatin contacts via bootstrapping deep learning.

Nucleic acids research
Interactions between regulatory elements are of crucial importance for the understanding of transcriptional regulation and the interpretation of disease mechanisms. Hi-C technique has been developed for genome-wide detection of chromatin contacts. Ho...

A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro.

Toxicological sciences : an official journal of the Society of Toxicology
The failure to predict kidney toxicity of new chemical entities early in the development process before they reach humans remains a critical issue. Here, we used primary human kidney cells and applied a systems biology approach that combines multidim...

[Effect of TNF-α on the ability of stem cells from human exfoliated deciduous teeth to promote osteoclastogenesis].

Shanghai kou qiang yi xue = Shanghai journal of stomatology
PURPOSE: To investigate the effect of tumor necrosis factor-α (TNF-α) on the ability of stem cells from human exfoliated deciduous teeth (SHED) to promote osteoclastogenesis.

Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions.

Assay and drug development technologies
There is a large amount of information in brightfield images that was previously inaccessible by using traditional microscopy techniques. This information can now be exploited by using machine-learning approaches for both image segmentation and the c...

Quality Control for High-Throughput Imaging Experiments Using Machine Learning in Cellprofiler.

Methods in molecular biology (Clifton, N.J.)
Robust high-content screening of visual cellular phenotypes has been enabled by automated microscopy and quantitative image analysis. The identification and removal of common image-based aberrations is critical to the screening workflow. Out-of-focus...

[Interleukin?22 promotes proliferation of fibroblast?like synoviocytes from patients with rheumatoid arthritis by inducing STAT3 phosphorylation].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University
OBJECTIVE: To clarify the mechanism by which interleukin?22 (IL?22) promotes the proliferation of fibroblast?like synoviocytes (FLS) from patients with rheumatoid arthritis (RA).