AIMC Topic: Nerve Tissue Proteins

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Real-time analysis of the behaviour of groups of mice via a depth-sensing camera and machine learning.

Nature biomedical engineering May 20, 2019
Preclinical studies of psychiatric disorders use animal models to investigate the impact of environmental factors or genetic mutations on complex traits such as decision-making and social interactions. Here, we introduce a method for the real-time an...
Behavioral Research Social Behavior Microfilament Proteins Mice, Knockout Mutation Video Recording Autistic Disorder Behavior, Animal Machine Learning Female Phenotype Animals Male Mice Disease Models, Animal Nerve Tissue Proteins
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DoGNet: A deep architecture for synapse detection in multiplexed fluorescence images.

PLoS computational biology May 13, 2019
Neuronal synapses transmit electrochemical signals between cells through the coordinated action of presynaptic vesicles, ion channels, scaffolding and adapter proteins, and membrane receptors. In situ structural characterization of numerous synaptic ...
Neural Networks, Computer Software Databases, Factual Nerve Tissue Proteins Neurons Synapses Cerebral Cortex Synaptic Transmission Microscopy, Fluorescence, Multiphoton Computer Simulation Animals Image Processing, Computer-Assisted Mice Computational Biology Models, Neurological
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Identification of esophageal cancer pathway deviation and construction of a diagnosis model using three kernel genes.

Journal of cellular physiology Mar 5, 2019
The purpose of this study is to better understand the role of interleukin 35 (IL35) in esophageal carcinoma by comparing the mRNA level in Barrett's esophageal mucosa and in matched normal squamous mucosa and to understand how the diagnosis model wor...
Humans Reproducibility of Results Biomarkers, Tumor Gene Expression Profiling Esophageal Squamous Cell Carcinoma Hepatocyte Nuclear Factor 1-beta Interleukin-12 Subunit p35 Databases, Genetic Early Detection of Cancer Nerve Tissue Proteins Predictive Value of Tests Transcriptome Esophageal Neoplasms Case-Control Studies Cyclic AMP Response Element-Binding Protein Deep Learning Gene Expression Regulation, Neoplastic Models, Genetic
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Evaluation of CNTNAP2 gene rs2107856 polymorphism in Turkish population with pseudoexfoliation syndrome.

International ophthalmology Dec 19, 2017
PURPOSE: To investigate rs2107856 single-nucleotide polymorphism (SNP) of CNTNAP2 gene in Turkish population with pseudoexfoliation and to correlate clinical characteristics with the genotypic profile.
Membrane Proteins Turkey Humans Nerve Tissue Proteins Retinal Ganglion Cells Cross-Sectional Studies Prospective Studies Visual Acuity Polymerase Chain Reaction Intraocular Pressure Female Tomography, Optical Coherence Polymorphism, Genetic Male Aged DNA Exfoliation Syndrome Middle Aged Aged, 80 and over Incidence Genotype
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CaspNeuroD: a knowledgebase of predicted caspase cleavage sites in human proteins related to neurodegenerative diseases.

Database : the journal of biological databases and curation Dec 26, 2016
BACKGROUND: A variety of neurodegenerative diseases (NDs) have been associated with deregulated caspase activation that leads to neuronal death. Caspases appear to be involved in the molecular pathology of NDs by directly cleaving important proteins....
Humans Machine Learning Polymorphism, Single Nucleotide Databases, Protein Nerve Tissue Proteins Neurodegenerative Diseases Caspases
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Genes with high penetrance for syndromic and non-syndromic autism typically function within the nucleus and regulate gene expression.

Molecular autism Mar 15, 2016
BACKGROUND: Intellectual disability (ID), autism, and epilepsy share frequent yet variable comorbidities with one another. In order to better understand potential genetic divergence underlying this variable risk, we studied genes responsible for mono...
Nerve Tissue Proteins Epilepsy Syndrome Cell Nucleus Gene Expression Regulation Autistic Disorder Protein Interaction Maps Genetic Association Studies Epigenomics Nuclear Proteins Databases, Genetic Chromatin Assembly and Disassembly Penetrance Risk Gene Ontology Neurogenesis Intellectual Disability Body Patterning Humans Autism Spectrum Disorder Comorbidity
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Neuroprotective effects of the Phellinus linteus ethyl acetate extract against H2O2-induced apoptotic cell death of SK-N-MC cells.

Nutrition research (New York, N.Y.) Nov 11, 2015
Numerous studies have suggested that neuronal cells are protected against oxidative stress-induced cell damage by antioxidants, such as polyphenolic compounds. Phellinus linteus (PL) has traditionally been used to treat various symptoms in East Asian...
Plant Extracts Neuroprotective Agents Apoptosis Biological Products Phellinus Polyphenols Nerve Tissue Proteins Humans Brain Republic of Korea Basidiomycota Cell Line, Tumor Fruiting Bodies, Fungal Oxidative Stress Acetates Gene Expression Regulation, Enzymologic Antioxidants Polysaccharides Oxidoreductases Neurons Ethnopharmacology Solvents Medicine, Korean Traditional MAP Kinase Signaling System
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Impact of sub and supra-threshold adaptation currents in networks of spiking neurons.

Journal of computational neuroscience Sep 24, 2015
Neuronal adaptation is the intrinsic capacity of the brain to change, by various mechanisms, its dynamical responses as a function of the context. Such a phenomena, widely observed in vivo and in vitro, is known to be crucial in homeostatic regulatio...
Potassium Channels, Voltage-Gated Nonlinear Dynamics Synapses Calcium Channels Cerebral Cortex Nerve Net Adaptation, Physiological Animals Models, Neurological Action Potentials Nerve Tissue Proteins Neurons Humans Neural Networks, Computer Computer Simulation
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Development of 3D-QSAR Model for Acetylcholinesterase Inhibitors Using a Combination of Fingerprint, Molecular Docking, and Structure-Based Pharmacophore Approaches.

Toxicological sciences : an official journal of the Society of Toxicology Jul 21, 2015
Acetylcholinesterase (AChE), a serine hydrolase vital for regulating the neurotransmitter acetylcholine in animals, has been used as a target for drugs and pesticides. With the increasing availability of AChE crystal structures, with or without ligan...
Acetylcholinesterase Humans Cholinesterase Inhibitors Expert Systems Catalytic Domain Molecular Conformation Quantitative Structure-Activity Relationship Binding Sites Peptide Mapping Nootropic Agents Databases, Protein Artificial Intelligence Nerve Tissue Proteins Animals Models, Molecular Molecular Docking Simulation GPI-Linked Proteins Imaging, Three-Dimensional Insecticides Computational Biology Ligands
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Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism.

BMC bioinformatics Jun 6, 2015
BACKGROUND: People with an autistic spectrum disorder (ASD) display a variety of characteristic behavioral traits, including impaired social interaction, communication difficulties and repetitive behavior. This complex neurodevelopment disorder is kn...
Autistic Disorder Gene Ontology Genome Calcium-Binding Proteins Social Behavior Membrane Potentials Cell Physiological Phenomena Cell Adhesion Molecules, Neuronal Neural Cell Adhesion Molecules Synaptic Potentials Genomics Rats Nerve Tissue Proteins Models, Molecular High-Throughput Nucleotide Sequencing Synapses Humans Phenotype Animals Mice
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