AI Medical Compendium Topic

Explore the latest research on artificial intelligence and machine learning in medicine.

Collagen Type I

Showing 1 to 10 of 12 articles

Clear Filters

[Effect of porcine small intestinal submucosa extracellular matrix in promoting vitality and functional gene expression of hepatocyte].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 29798552
OBJECTIVE: To investigate the effect of porcine small intestinal submucosa extracellular matrix (PSISM) on the vitality and gene regulation of hepatocyte so as to lay the experimental foundation for the application of PSISM in liver tissue engineerin...
Animals Cell Differentiation Cells, Cultured Collagen Type I Extracellular Matrix Gene Expression Hepatocytes Intestine, Small Swine
View on PubMed DOI

Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model.

Drug design, development and therapy 29317799
OBJECTIVES: A knee joint contracture, a loss in passive range of motion (ROM), can be caused by prolonged immobility. In a rat knee immobilization flexion contracture model, the posterior capsule was shown to contribute to an irreversible limitation ...
Animals Biomechanical Phenomena Collagen Type I Collagen Type III Collagenases Contracture Disease Models, Animal Hindlimb Suspension Injections, Intra-Articular Joint Capsule Joints Male Proteolysis Range of Motion, Articular Rats, Sprague-Dawley Recovery of Function Time Factors
View on PubMed DOI

The protective effects of bone morphogenetic protein-7 against epithelial injury and matrix metalloproteases upregulation induced by silica in vitro.

Human & experimental toxicology 28838258
OBJECTIVE: We investigate the effects of bone morphogenetic protein-7 (BMP-7) on models with silica-induced and macrophage-mediated fibrosis and its possible mechanisms in vitro.
Animals Bone Morphogenetic Protein 7 Cadherins Cell Line Collagen Type I Collagen Type III Epithelial Cells Fibronectins Hydroxyproline Matrix Metalloproteinases Mice Pulmonary Surfactant-Associated Protein C Quartz Rats Smad Proteins Up-Regulation Vimentin
View on PubMed DOI

A machine learning approach for the identification of new biomarkers for knee osteoarthritis development in overweight and obese women.

Osteoarthritis and cartilage 28899843
OBJECTIVE: Knee osteoarthritis (OA) is among the higher contributors to global disability. Despite its high prevalence, currently, there is no cure for this disease. Furthermore, the available diagnostic approaches have large precision errors and low...
Arthralgia Biomarkers Collagen Type I Collagen Type II Comorbidity Diet Female Fruit Heuristics Humans Incidence Machine Learning Middle Aged Muscle Strength Obesity Osteoarthritis, Knee Overweight Peptide Fragments Principal Component Analysis Quadriceps Muscle Reproducibility of Results
View on PubMed DOI

A machine learning approach to predict cellular mechanical stresses in response to chemical perturbation.

Biophysical journal 37496269
Mechanical stresses generated at the cell-cell level and cell-substrate level have been suggested to be important in a host of physiological and pathological processes. However, the influence various chemical compounds have on the mechanical stresses...
Cells, Cultured Chalcone Collagen Type I Human Umbilical Vein Endothelial Cells Humans Linear Models Machine Learning Mechanotransduction, Cellular Stress, Mechanical Support Vector Machine Time-Lapse Imaging
View on PubMed DOI

Multimodal characterization of the collagen hydrogel structure and properties in response to physiologically relevant pH fluctuations.

Acta biomaterialia 38417647
pH fluctuations within the extracellular matrix (ECM) and its principal constituent collagen, particularly in solid tumors and chronic wounds, may influence its structure and function. Whereas previous research examined the impact of pH on collagen f...
Artificial Intelligence Collagen Collagen Type I Extracellular Matrix Hydrogels
View on PubMed DOI

Mechanisms of QingRe HuoXue Formula in atherosclerosis Treatment: An integrated approach using Bioinformatics, Machine Learning, and experimental validation.

International immunopharmacology 39137627
BACKGROUND: Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease. QingRe HuoXue Formula (QRHXF), a common prescription of traditional Chinese medicine, has a definite effect on the cli...
Animals Atherosclerosis Collagen Type I Collagen Type I, alpha 1 Chain Computational Biology Disease Models, Animal Drugs, Chinese Herbal Gene Expression Profiling Humans Machine Learning Male Mice Mice, Inbred C57BL Molecular Docking Simulation Plaque, Atherosclerotic
View on PubMed DOI

The role of endothelial cell-related gene COL1A1 in prostate cancer diagnosis and immunotherapy: insights from machine learning and single-cell analysis.

Biology direct 39780278
BACKGROUND: Endothelial cells are integral components of the tumor microenvironment and play a multifaceted role in tumor immunotherapy. Targeting endothelial cells and related signaling pathways can improve the effectiveness of immunotherapy by norm...
Collagen Type I Collagen Type I, alpha 1 Chain Endothelial Cells Humans Immunotherapy Machine Learning Male Prognosis Prostatic Neoplasms Single-Cell Analysis Tumor Microenvironment
View on PubMed DOI

Differential gene expression analysis and machine learning identified structural, TFs, cytokine and glycoproteins, including SOX2, TOP2A, SPP1, COL1A1, and TIMP1 as potential drivers of lung cancer.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 39888730
BACKGROUND: Lung cancer is a primary global health concern, responsible for a considerable portion of cancer-related fatalities worldwide. Understanding its molecular complexities is crucial for identifying potential targets for treatment. The goal i...
Biomarkers, Tumor Collagen Type I Collagen Type I, alpha 1 Chain DNA Topoisomerases, Type II Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulatory Networks Humans Lung Neoplasms Machine Learning Osteopontin Poly-ADP-Ribose Binding Proteins Protein Interaction Maps SOXB1 Transcription Factors Tissue Inhibitor of Metalloproteinase-1
View on PubMed DOI

Identification of novel biomarkers for atherosclerosis using single-cell RNA sequencing and machine learning.

Mammalian genome : official journal of the International Mammalian Genome Society 39400603
Atherosclerosis (AS) is a predominant etiological factor in numerous cardiovascular diseases, with its associated complications such as myocardial infarction and stroke serving as major contributors to worldwide mortality rates. Here, we devised depe...
Animals Atherosclerosis Biomarkers Collagen Type I Collagen Type I, alpha 1 Chain Gene Expression Profiling Gene Regulatory Networks Humans Machine Learning Mice Sequence Analysis, RNA Single-Cell Analysis
View on PubMed DOI
Popular Topics
Recent Journals