AIMC Topic: Dose-Response Relationship, Drug

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Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults.

Clinical nutrition (Edinburgh, Scotland) Dec 24, 2015
BACKGROUND & AIMS: Mortality resulting from influenza (flu) virus infections occurs primarily in the elderly through declining immunity. Studies in mice have suggested beneficial effects of selenium (Se) supplementation on immunity to flu but similar...
Immunoglobulins Immunoglobulin A Double-Blind Method Saliva Influenza, Human Influenza Vaccines Diet Selenium Immunity, Cellular Antibodies, Viral Cell Proliferation Body Mass Index Dose-Response Relationship, Drug Dietary Supplements Female T-Lymphocytes Male Middle Aged Humans Cytokines
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Inhibition of bacterial surface colonization by immobilized silver nanoparticles depends critically on the planktonic bacterial concentration.

Journal of colloid and interface science Dec 23, 2015
Immobilization of antimicrobial silver nanoparticles (AgNPs) on surfaces has been proposed as a method to inhibit biofouling or as a possible route by which incidental releases of AgNPs may interfere with biofilms in the natural environment or in was...
Anti-Bacterial Agents Dose-Response Relationship, Drug Microbial Sensitivity Tests Plankton Structure-Activity Relationship Surface Properties Metal Nanoparticles Pseudomonas fluorescens Silver
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Fit-for-purpose chromatographic method for the determination of amikacin in human plasma for the dosage control of patients.

Talanta Dec 21, 2015
In this paper, a simple, rapid and sensitive method based on liquid chromatography with fluorimetric detection (HPLC-FLD) for the determination of amikacin (AMK) in human plasma is developed. Determination is performed by pre-column derivatization of...
Humans Anti-Bacterial Agents Dose-Response Relationship, Drug Bacterial Infections Chromatography, High Pressure Liquid Quality Control Fluorometry Spectrophotometry, Ultraviolet Amikacin
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Adjuvant Carboplatin Treatment in 115 Patients With Stage I Seminoma: Retrospective Multicenter Survey.

Clinical genitourinary cancer Dec 17, 2015
BACKGROUND: The administration of carboplatin AUC 7 has become a standard adjuvant option for patients undergoing orchiectomy for stage I seminoma, in alternative to radiotherapy on retroperitoneal lymphnodes or surveillance. The toxicity of AUC 7 ca...
Humans Retrospective Studies Antineoplastic Agents Treatment Outcome Testicular Neoplasms Seminoma Dose-Response Relationship, Drug Young Adult Adult Male Middle Aged Italy Carboplatin Chemotherapy, Adjuvant
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Edoxaban vs warfarin in patients with nonvalvular atrial fibrillation in the US Food and Drug Administration approval population: An analysis from the Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48 (ENGAGE AF-TIMI 48) trial.

American heart journal Dec 1, 2015
BACKGROUND: Edoxaban is a specific anti-Xa inhibitor that, in comparison to warfarin, has been found to be noninferior for the prevention of stroke or systemic embolism (SSE) and to reduce bleeding significantly in patients with nonvalvular atrial fi...
Drug Approval United States Food and Drug Administration Thiazoles Factor Xa Factor Xa Inhibitors Warfarin Stroke Myocardial Infarction Humans Atrial Fibrillation Female Aged Pyridines Anticoagulants Male Thrombolytic Therapy Blood Coagulation United States Double-Blind Method Dose-Response Relationship, Drug
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Reduction of Trial-to-Trial Perceptual Variability by Intracortical Tonic Inhibition.

Neural computation Nov 24, 2015
Variability is a prominent characteristic of cognitive brain function. For instance, different trials of presentation of the same stimulus yield higher variability in its perception: subjects sometimes fail in perceiving the same stimulus. Perceptual...
Humans Cerebral Cortex gamma-Aminobutyric Acid Nerve Net Neural Inhibition Membrane Potentials Neural Networks, Computer Models, Neurological Dose-Response Relationship, Drug Neurons
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Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway.

International journal of clinical and experimental pathology Nov 1, 2015
Increasing evidences have indicated the role of garlicin in inhibiting the progression of various tumors including glioma, pulmonary carcinoma and pancreatic carcinoma, via mediating cell apoptosis or cell cycle. The regulatory effect and related mol...
Phosphatidylinositol 3-Kinase Phosphoinositide-3 Kinase Inhibitors Dose-Response Relationship, Drug Antineoplastic Agents, Phytogenic Phosphorylation Proto-Oncogene Proteins c-akt Allyl Compounds Bile Duct Neoplasms Cell Proliferation Humans Protein Kinase Inhibitors Disulfides Signal Transduction Cell Line, Tumor Cholangiocarcinoma Cell Movement Neoplasm Invasiveness
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Follicle-stimulating hormone-induced rescue of cumulus cell apoptosis and enhanced development ability of buffalo oocytes.

Domestic animal endocrinology Oct 31, 2015
The effect of follicle-stimulating hormone (FSH) on apoptotic status of cumulus cells, expression of proapoptotic and antiapoptotic genes, and development rate of in vitro fertilization-produced buffalo embryos were investigated. FSH supplementation ...
Follicle Stimulating Hormone Oocytes Animals Embryo Culture Techniques Buffaloes In Vitro Oocyte Maturation Techniques Apoptosis Gene Expression Regulation Cumulus Cells Dose-Response Relationship, Drug DNA Fragmentation Female
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Effect of earthworm active protein on fibroblast proliferation and its mechanism.

Pharmaceutical biology Oct 7, 2015
CONTEXT: Earthworms have been used as a traditional medicine in China from thousands of years. In recent years, research has demonstrated that earthworm extracts might promote wound healing; however, its mechanism is still unknown.
Biological Factors Oligochaeta Fibroblasts Dose-Response Relationship, Drug Cell Survival NIH 3T3 Cells Animals Mice Cell Proliferation
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Bioequivalence and comparative pharmacodynamics of insulin lispro 200 U/mL relative to insulin lispro (Humalog®) 100 U/mL.

Clinical pharmacology in drug development Oct 5, 2015
Insulin lispro 200 U/mL (IL200) is a new strength formulation of insulin lispro (Humalog®, IL100), developed as an option for diabetic patients on higher daily mealtime insulin doses. This phase 1, open-label, 2-sequence, 4-period crossover, randomiz...
Area Under Curve Cross-Over Studies Insulin Lispro Male Humans Therapeutic Equivalency Middle Aged Female Glucose Clamp Technique Hypoglycemic Agents Young Adult Dose-Response Relationship, Drug Adult
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