AIMC Topic: Cell Proliferation

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Nuquantus: Machine learning software for the characterization and quantification of cell nuclei in complex immunofluorescent tissue images.

Scientific reports Mar 23, 2016
Determination of fundamental mechanisms of disease often hinges on histopathology visualization and quantitative image analysis. Currently, the analysis of multi-channel fluorescence tissue images is primarily achieved by manual measurements of tissu...
Microscopy, Confocal Cell Proliferation Cell Survival Myocytes, Cardiac Cell Nucleus Machine Learning Software Animals Image Processing, Computer-Assisted Fluorescent Antibody Technique Humans
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Optimized Repopulation of Tendon Hydrogel: Synergistic Effects of Growth Factor Combinations and Adipose-Derived Stem Cells.

Hand (New York, N.Y.) Mar 15, 2016
Tendon-derived extracellular matrix (ECM) hydrogel has been shown to augment tendon healing in vivo. We hypothesized that reseeding of the gel with adipose-derived stem cells (ASCs) could further assist repopulation of the gel and that combinations ...
Tissue Engineering Animals Stem Cell Transplantation Tissue Scaffolds Cell Proliferation Rats, Sprague-Dawley Tendons Adipose Tissue Dose-Response Relationship, Drug Guided Tissue Regeneration Hydrogels Intercellular Signaling Peptides and Proteins Drug Synergism Extracellular Matrix
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Locality Sensitive Deep Learning for Detection and Classification of Nuclei in Routine Colon Cancer Histology Images.

IEEE transactions on medical imaging Feb 4, 2016
Detection and classification of cell nuclei in histopathology images of cancerous tissue stained with the standard hematoxylin and eosin stain is a challenging task due to cellular heterogeneity. Deep learning approaches have been shown to produce en...
Neural Networks, Computer Machine Learning Colon Cell Proliferation Colonic Neoplasms Image Interpretation, Computer-Assisted Cell Nucleus Histocytochemistry Humans
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Effect of imatinib on growth of experimental endometriosis in rats.

European journal of obstetrics, gynecology, and reproductive biology Dec 25, 2015
OBJECTIVE: Currently, medical and surgical treatment options for endometriosis are limited due to suboptimal efficacy, and also safety and tolerance issues. Long-term use of gonadotrophin-releasing hormone analogs, androgenes, and the danazol, which ...
Ovarian Follicle Anastrozole Peritoneal Diseases Proto-Oncogene Proteins c-kit Peritoneum Imatinib Mesylate Nitriles Aromatase Inhibitors Cell Proliferation Angiogenesis Inhibitors Endometrium Disease Models, Animal bcl-2-Associated X Protein Endometriosis Vascular Endothelial Growth Factor A Triazoles Transplantation, Autologous Female Animals Rats
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Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults.

Clinical nutrition (Edinburgh, Scotland) Dec 24, 2015
BACKGROUND & AIMS: Mortality resulting from influenza (flu) virus infections occurs primarily in the elderly through declining immunity. Studies in mice have suggested beneficial effects of selenium (Se) supplementation on immunity to flu but similar...
Middle Aged Diet Selenium Immunity, Cellular Antibodies, Viral Cell Proliferation Body Mass Index Dose-Response Relationship, Drug Dietary Supplements Humans Cytokines Female T-Lymphocytes Male Immunoglobulins Double-Blind Method Immunoglobulin A Saliva Influenza, Human Influenza Vaccines
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Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway.

International journal of clinical and experimental pathology Nov 1, 2015
Increasing evidences have indicated the role of garlicin in inhibiting the progression of various tumors including glioma, pulmonary carcinoma and pancreatic carcinoma, via mediating cell apoptosis or cell cycle. The regulatory effect and related mol...
Protein Kinase Inhibitors Cholangiocarcinoma Phosphatidylinositol 3-Kinase Phosphoinositide-3 Kinase Inhibitors Humans Phosphorylation Cell Movement Cell Line, Tumor Proto-Oncogene Proteins c-akt Neoplasm Invasiveness Cell Proliferation Bile Duct Neoplasms Dose-Response Relationship, Drug Signal Transduction Disulfides Antineoplastic Agents, Phytogenic Allyl Compounds
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Effect of earthworm active protein on fibroblast proliferation and its mechanism.

Pharmaceutical biology Oct 7, 2015
CONTEXT: Earthworms have been used as a traditional medicine in China from thousands of years. In recent years, research has demonstrated that earthworm extracts might promote wound healing; however, its mechanism is still unknown.
Oligochaeta Dose-Response Relationship, Drug Cell Survival NIH 3T3 Cells Biological Factors Animals Mice Cell Proliferation Fibroblasts
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Machine learning Reveals ATM and CNOT6L as critical factors in Cataract pathogenesis.

Experimental eye research Aug 1, 2025
OBJECTIVE: Cataract, a common age-related blinding eye disease, has a complex pathogenesis. This study aims to identify key genes and potential mechanisms associated with cataracts, offering new targets and insights for its prevention and treatment.
Cell Proliferation Transcription Factors Apoptosis Humans Cataract Epithelial Cells Machine Learning Lens, Crystalline Animals Gene Expression Regulation Oxidative Stress Ataxia Telangiectasia Mutated Proteins
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Anticoagulation colloidal microrobots based on heparin-mimicking polymers.

Journal of colloid and interface science Aug 1, 2025
Coagulation within blood vessels is a major cause of cardiovascular disease and global mortality, highlighting the urgent need for effective anticoagulant strategies. In this study, we introduce a dynamic and highly efficient anticoagulant platform, ...
Robotics Heparin Anticoagulants Blood Coagulation Gold Humans Cell Proliferation Particle Size Colloids Human Umbilical Vein Endothelial Cells Polymers Surface Properties Myocytes, Smooth Muscle
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Multi-omics identifies OSM-OSMR as a key receptor-ligand in the tumor environment of endometrial adenocarcinoma.

International immunopharmacology Jul 28, 2025
Endometrial adenocarcinoma carries a bleak prognosis, and the molecular markers that evaluate the progression of endometrial adenocarcinoma to advanced stages remain uncertain. Cell-cell communication plays a crucial role in the tumor microenvironmen...
Gene Expression Profiling Transcriptome Cell Line, Tumor Mice Multiomics Prognosis Female Tumor Microenvironment Animals Mice, Nude Ligands Endometrial Neoplasms Oncostatin M Oncostatin M Receptor beta Subunit Humans Gene Expression Regulation, Neoplastic Cell Proliferation Signal Transduction Adenocarcinoma
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