AIMC Topic: Cell Proliferation
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Structure-based artificial intelligence-aided design of MYC-targeting degradation drugs for cancer therapy.
Biochemical and biophysical research communications
Jun 20, 2025
The MYC protein is an oncoprotein that plays a crucial role in various cancers. Although its significance has been well recognized in research, the development of drugs targeting MYC remains relatively slow. In this study, we developed a novel MYC pe...
Machine learning-based bioactivity prediction of porphyrin derivatives: molecular descriptors, clustering, and model evaluation.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
Jun 1, 2025
Understanding the relationship between molecular structure and bioactivity is crucial for optimizing porphyrin-based therapeutics. By integrating cheminformatics techniques with machine learning models, our work enables the efficient classification o...
Deciphering the mechanism of baicalein in cervical cancer via bioinformatics, machine learning and computational simulations: PIM1 and CDK2 are key target proteins.
International journal of biological macromolecules
Jun 1, 2025
Cervical cancer is one of the leading causes of death among women worldwide. Current treatments are limited by chemoresistance and chemotherapeutic agents' adverse effects, prompting the search for better therapeutic alternatives. Baicalein, a natura...
Deep learning-driven imaging of cell division and cell growth across an entire eukaryotic life cycle.
Molecular biology of the cell
Jun 1, 2025
The life cycle of eukaryotic microorganisms involves complex transitions between states such as dormancy, mating, meiosis, and cell division, which are often studied independently from each other. Therefore, most microbial life cycles are theoretical...
Artificial intelligence-driven microRNA signature for early detection of gastric cancer: discovery and clinical functional exploration.
British journal of cancer
Jun 1, 2025
BACKGROUND: Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide, with late-stage diagnoses frequently leading to poor outcomes. This underscores the need for effective early-stage gastric cancer (ESGC) diagnostics.
Machine learning identifies SRD5A3 as a propionate-related prognostic biomarker in triple-negative breast cancer.
Scientific reports
May 29, 2025
The increased risk of recurrence and metastasis are obstacles to treating TNBC. Propionate-related genes play an important role in tumor development and immune cell infiltration. The study was to identify the association between propionate-related ge...
Effect of Cell-Cell Interaction on Single-Cell Behavior Revealed by a Deep Learning-Aided High-Throughput Addressable Single-Cell Coculture System.
Analytical chemistry
May 13, 2025
Cell-cell interactions are crucial for understanding various physiological and pathological processes, yet conventional population-level methods fail to disclose the heterogeneity at a single-cell resolution. Single-cell coculture systems that isolat...
Development of a prognostic model for osteosarcoma based on macrophage polarization-related genes using machine learning: implications for personalized therapy.
Clinical and experimental medicine
May 9, 2025
While neoadjuvant chemotherapy combined with surgical resection has improved the prognosis for patients with osteosarcoma, its impact on metastatic and recurrent cases remains limited. Immunotherapy is emerging as a promising alternative. However, th...
A quantitative characterization of the heterogeneous response of glioblastoma U-87 MG cell line to temozolomide.
Scientific reports
May 8, 2025
Most cancers are genetically and phenotypically heterogeneous. This includes subpopulations of cells with different levels of sensitivity to chemotherapy, which may lead to treatment failure as the more resistant cells can survive drug treatment and ...
Artificial Intelligence-Guided Identification of IGFBP7 as a Critical Indicator in Lactic Metabolism Determines Immunotherapy Response in Stomach Adenocarcinoma.
Journal of cellular and molecular medicine
Jan 1, 2025
Due to considerable tumour heterogeneity, stomach adenocarcinoma (STAD) has a poor prognosis and varies in response to treatment, making it one of the main causes of cancer-related mortality globally. Recent data point to a significant role for metab...
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